Evidence map›Paper›PMID 34585487›Full record

ArticleHIV medicine2022

Time trends in cancer incidence in Australian people living with HIV between 1982 and 2012.

Ian K J Wong, Andrew E Grulich, Isobel Mary Poynten, Mark N Polizzotto, Marina T van Leeuwen, Janaki Amin, Skye McGregor, Matthew Law, David J Templeton, Claire M Vajdic and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in HIV medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Age and Cancer Incidence in 5.2 Million People With Human Immunodeficiency Virus (HIV): The South African HIV Cancer Match Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Ian K J WongThe Kirby Institute, UNSW Sydney, Sydney, NSW, Australia.ORCID 0000-0001-8206-4101
Andrew E GrulichThe Kirby Institute, UNSW Sydney, Sydney, NSW, Australia.
Isobel Mary PoyntenThe Kirby Institute, UNSW Sydney, Sydney, NSW, Australia.
Mark N PolizzottoThe Kirby Institute, UNSW Sydney, Sydney, NSW, Australia.
Marina T van LeeuwenCentre for Big Data Research in Health, UNSW Sydney, Sydney, NSW, Australia.
Janaki AminDepartment of Health Systems and Populations, Faculty of Medicine and Health Science, Macquarie University, Sydney, NSW, Australia.
Skye McGregorThe Kirby Institute, UNSW Sydney, Sydney, NSW, Australia.
Matthew LawThe Kirby Institute, UNSW Sydney, Sydney, NSW, Australia.
David J TempletonThe Kirby Institute, UNSW Sydney, Sydney, NSW, Australia.
Claire M VajdicCentre for Big Data Research in Health, UNSW Sydney, Sydney, NSW, Australia.
Fengyi JinThe Kirby Institute, UNSW Sydney, Sydney, NSW, Australia.
UNSW Sydney · AUMacquarie University · AUThe University of Sydney · AU

Funding

The Asia-Pacific HIV Research CollaborationU01AI069907 · NIAID · FOUNDATION FOR AIDS RESEARCH · PI ANNETTE H SOHN · 2006 to 2026
$44.8M
NIAID NIH HHS U01 AI069907
6 · The paper itself

Abstract

objectivesThe aim of the study was to describe time trends in cancer incidence in people living with HIV (PLHIV) in Australia between 1982 and 2012.

methodsA population-based prospective study was conducted using data linkage between the national HIV and cancer registries. Invasive cancers identified in PLHIV were grouped into AIDS-defining cancers (ADCs), infection-related non-ADCs (NADCs), and non-infection-related NADCs. Crude and age-standardized incidence rates of cancers were calculated and compared over five time periods: 1982-1995, 1996-1999, 2000-2004, 2005-2008 and 2009-2012, roughly reflecting advances in HIV antiretroviral therapy. Standardized incidence ratios (SIRs) compared with the Australian general population were calculated for each time period. Generalized linear models were developed to assess time trends in crude and age-standardized incidences.

resultsFor ADCs, the crude and age-standardized incidences of Kaposi sarcoma and non-Hodgkin lymphoma substantially declined over time (P-trend < 0.001 for all) but SIRs remained significantly elevated. For infection-related NADCs, there were significant increases in the crude incidences of anal, liver and head and neck cancers. Age-standardized incidences increased for anal cancer (P-trend = 0.002) and liver cancer (P-trend < 0.001). SIRs were significantly elevated for anal cancer, liver cancer and Hodgkin lymphoma. For non-infection-related NADCs, the crude incidence of colorectal, lung and prostate cancers increased over time, but age-standardized incidences remained stable.

conclusionsContinuous improvements and high coverage of antiretroviral therapy have reduced the incidence of ADCs in PLHIV in Australia. Clinical monitoring of anal and liver cancers in people living with HIV should be performed, given the increasing incidence of these cancers.

Indexed as

Anus NeoplasmsHIV InfectionsNeoplasmsSarcoma, KaposiAntiretroviral Therapy, Highly ActiveAustraliaHumansIncidenceMaleProspective StudiesRisk FactorsAustraliacancerdata linkageHIVincidence

Identifiers

PMID34585487
PMCPMC10499845
OpenAlexW3204106841

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.