ArticleBrain structure & function2022
Genetic and environmental influences of variation in diffusion MRI measures of white matter microstructure.
Article in Brain structure & function, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- White matter microstructure in relatives of people with schizophrenia or bipolar disorder: an ENIGMA meta-analysis.Molecular psychiatry · 2026Pooled it
- Genetic and environmental influence on white matter: insight from an Italian twin population study.Frontiers in human neuroscience · 2026Article
- In vivo mapping of infant brain microstructure with neurite orientation dispersion and density imaging.Brain structure & function · 2025Review
- The Shape of the Brain's Connections Is Predictive of Cognitive Performance: An Explainable Machine Learning Study.Human brain mapping · 2025Review
- Topological state-space estimation of functional human brain networks.PLoS computational biology · 2024Article
- Moving toward elucidating alternative motor pathway structures post-stroke: the value of spinal cord neuroimaging.Frontiers in neurology · 2024Review
- Microstructural Properties of the Cerebellar Peduncles in Children With Developmental Language Disorder.Neurobiology of language (Cambridge, Mass.) · 2024Article
- A role for the fornix in temporal sequence memory.The European journal of neuroscience · 2023Article
- Childhood inhibition predicts adolescent social anxiety: Findings from a longitudinal twin study.Development and psychopathology · 2022Article
- Longitudinal assessment of early-life white matter development with quantitative relaxometry in nonhuman primates.NeuroImage · 2022Article
- Pediatric Brain Maturation and Migration Disorders.Diagnostics (Basel, Switzerland) · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Quantitative neuroimaging studies in twin samples can investigate genetic contributions to brain structure and microstructure. Diffusion tensor imaging (DTI) studies with twin samples have shown moderate to high heritability in white matter microstructure. This study investigates the genetic and environmental contributions of another widely used diffusion MRI model not yet applied to twin studies, neurite orientation dispersion and density imaging (NODDI). The NODDI model is a multicompartment model of the diffusion-weighted MRI signal, providing estimates of neurite density (ND) and the orientation dispersion index (ODI). A cohort of monozygotic (MZ) and same-sex dizygotic (DZ) twins (N = 460 individuals) between 13 and 24 years of age were scanned with a multi-shell diffusion weighted imaging protocol. Select white matter (WM) regions of interest (ROI) were extracted. Biometric structural equation modeling estimated the relative contributions from additive genetic (A) and common (C) and unique environmental (E) factors. Genetic factors for the NODDI measures accounted for 91% and 65% of the variation of global ND and ODI, respectively, compared with 83% for FA. We observed higher heritability for ND than both FA and ODI in 25 of 30 discrete white matter regions that we examined, suggesting ND may be more sensitive to underlying genetic sources of variation. This study demonstrated that genetic factors play a key role in the development of white matter microstructure using both DTI and NODDI.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.