Evidence map›Paper›PMID 34585241›Full record

ArticleThe Journal of experimental biology2021

Myogenic contraction of a somatic muscle powers rhythmic flow of hemolymph through Drosophila antennae and generates brain pulsations.

Alan R Kay, Daniel F Eberl, Jing W Wang

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of experimental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pharmacological insights intoFrontiers in pharmacology · 2025
    Pooled it
  2. Article
  3. Review
  4. Article
  5. The opportunities and challenges of usingFrontiers in physiology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Alan R KayDepartment of Biology, University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0002-2820-6188
Daniel F EberlDepartment of Biology, University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0001-9982-9895
Jing W WangNeurobiology Section, Division of Biological Sciences, University of California, San Diego, CA 92093, USA.ORCID 0000-0001-6291-5802
University of Iowa · USUniversity of California San Diego · US

Funding

Genetic analysis of state-dependent chemosensory processingR01DC016466 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SU, CHIH-YING · 2017 to 2025
$3.6M
Drosophila: Metabolic Modulation of Olfactory Circuit Function/Feeding BehaviorR01DK092640 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WANG, JING W · 2011 to 2020
$3.1M
Gut-brain communication of nutrient informationR01DK127516 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WANG, JING W · 2020 to 2023
$1.4M
NIDCD NIH HHS R01 DC016466NIDDK NIH HHS R01 DK092640NIDDK NIH HHS R01 DK127516NIH HHS R01DK092640
6 · The paper itself

Abstract

Hemolymph is driven through the antennae of Drosophila melanogaster by the rhythmic contraction of muscle 16 (m16), which runs through the brain. Contraction of m16 results in the expansion of an elastic ampulla, opening ostia and filling the ampulla. Relaxation of the ampullary membrane forces hemolymph through vessels into the antennae. We show that m16 is an auto-active rhythmic somatic muscle. The activity of m16 leads to the rapid perfusion of the antenna by hemolymph. In addition, it leads to the rhythmic agitation of the brain, which could be important for clearing the interstitial space.

Indexed as

DrosophilaHemolymphAnimalsBrainDrosophila melanogasterHeartMuscle ContractionMusclesCirculatory systemHeartPulsatile organsPulsatility

Identifiers

PMID34585241
PMCPMC8545754
OpenAlexW3204821055

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.