Evidence map›Paper›PMID 34585199›Full record

ArticleLab on a chip2021

Point-of-care microchip electrophoresis for integrated anemia and hemoglobin variant testing.

Ran An, Yuncheng Man, Shamreen Iram, Erdem Kucukal, Muhammad Noman Hasan, Yuning Huang, Utku Goreke, Allison Bode, Ailis Hill, Kevin Cheng and 5 more

Open access · greenAbstract read
In one paragraph

Article in Lab on a chip, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 34 citations in OpenAlex.

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  10. A pH-mediated field amplification sample stacking technique based on portable microchip electrophoresis heavy metal ion detection system.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2023
    Article
  11. Artificial Intelligence in Point-of-Care Testing.Annals of laboratory medicine · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Ran AnDepartment of Mechanical and Aerospace Engineering, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106, USA. umut@case.edu.
Yuncheng ManDepartment of Mechanical and Aerospace Engineering, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106, USA. umut@case.edu.ORCID 0000-0002-3034-5523
Shamreen IramDepartment of Physics, Case Western Reserve University, Cleveland, OH 44106, USA.ORCID 0000-0002-4354-7407
Erdem KucukalDepartment of Mechanical and Aerospace Engineering, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106, USA. umut@case.edu.
Muhammad Noman HasanDepartment of Mechanical and Aerospace Engineering, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106, USA. umut@case.edu.ORCID 0000-0003-1413-6139
Yuning HuangDepartment of Mechanical and Aerospace Engineering, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106, USA. umut@case.edu.
Utku GorekeDepartment of Mechanical and Aerospace Engineering, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106, USA. umut@case.edu.
Allison BodeDepartment of Mechanical and Aerospace Engineering, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106, USA. umut@case.edu.
Ailis HillDepartment of Mechanical and Aerospace Engineering, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106, USA. umut@case.edu.ORCID 0000-0001-7475-2748
Kevin ChengDepartment of Mechanical and Aerospace Engineering, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106, USA. umut@case.edu.
Zoe SekyondaDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.
Sanjay P AhujaDepartment of Pediatrics, Division of Hematology and Oncology, University Hospitals Rainbow Babies and Children's Hospital, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Jane A LittleDivision of Hematology & UNC Blood Research Center, Department of Medicine, University of North Carolina, Chapel Hill, NC, USA.
Michael HinczewskiDepartment of Physics, Case Western Reserve University, Cleveland, OH 44106, USA.
Umut A GurkanDepartment of Mechanical and Aerospace Engineering, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106, USA. umut@case.edu.ORCID 0000-0002-0331-9960
Case Western Reserve University · USRainbow Babies & Children's Hospital · US

Funding

The Center for Advancing Point of Care in Heart, Lung, Blood and Sleep DiseasesU54HL143541 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Apurv Soni · 2018 to 2026
$141.0M
HLS-Affordable, quantitative microchip-electrophoresis for sickle cell disease screeningR44HL140739 · NHLBI · HEMEX HEALTH, INC. · PI GALEN, PETER · 2018 to 2025
$4.7M
Standardized Monitoring of Cellular Adhesion to Improve Clinical Care in Sickle Cell DiseaseR01HL133574 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI GURKAN, UMUT A., LITTLE, JANE · 2016 to 2020
$2.0M
CWRU- Cardiovascular Research Training ProgramT32HL134622 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI JAIN, MUKESH KUMAR, PROWELLER, AARON · 2017 to 2021
$1.9M
Portable, affordable, quantitative microchip electrophoresis for hemoglobin A1C testingR41DK119048 · NIDDK · HEMEX HEALTH, INC. · PI GALEN, PETER · 2018 to 2018
$225k
Portable, affordable, quantitative microchip electrophoresis system for integrated anemia and hemoglobin variant testingR41HL151015 · NHLBI · HEMEX HEALTH, INC. · PI GALEN, PETER · 2020 to 2020
$225k
NHLBI NIH HHS R01 HL133574NHLBI NIH HHS R41 HL151015NHLBI NIH HHS R44 HL140739NHLBI NIH HHS T32 HL134622NHLBI NIH HHS U54 HL143541NIDDK NIH HHS R41 DK119048
6 · The paper itself

Abstract

Anemia affects over 25% of the world's population with the heaviest burden borne by women and children. Genetic hemoglobin (Hb) variants, such as sickle cell disease, are among the major causes of anemia. Anemia and Hb variant are pathologically interrelated and have an overlapping geographical distribution. We present the first point-of-care (POC) platform to perform both anemia detection and Hb variant identification, using a single paper-based electrophoresis test. Feasibility of this new integrated diagnostic approach is demonstrated

Indexed as

Anemia, Sickle CellElectrophoresis, MicrochipFemaleHematologic TestsHemoglobinsHumansPoint-of-Care SystemsPoint-of-Care TestingHemoglobins

Identifiers

PMID34585199
PMCPMC9714341
OpenAlexW3196021468

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.