Evidence map›Paper›PMID 34585129›Full record

ArticleEClinicalMedicine2021

Outpatient and inpatient anticoagulation therapy and the risk for hospital admission and death among COVID-19 patients.

Sameh M Hozayen, Diana Zychowski, Sydney Benson, Pamela L Lutsey, Jasmin Haslbauer, Alexandar Tzankov, Zachary Kaltenborn, Michael Usher, Surbhi Shah, Christopher J Tignanelli and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EClinicalMedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
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  9. ISTH guidelines for antithrombotic treatment in COVID-19.Journal of thrombosis and haemostasis : JTH · 2022
    Article
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  17. Review
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  20. Assessment of Healthcare Resource Utilization by Anticoagulant Heparinoid Dosage Level in Patients Hospitalized with COVID-19.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Sameh M HozayenDepartment of Medicine, Division of General Internal Medicine, Assistant Professor of Medicine, Hospitalist, University of Minnesota, Mayo Building, 420 Delaware Street, SE, 6 Floor, Room D694, Minneapolis, MN 55455, United States.
Diana ZychowskiDepartment of Medical Education, University of Minnesota, United States.
Sydney BensonDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, United States.
Pamela L LutseyDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, United States.
Jasmin HaslbauerPathology, Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Switzerland.
Alexandar TzankovPathology, Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Switzerland.
Zachary KaltenbornDepartment of Medicine, Division of General Internal Medicine, Assistant Professor of Medicine, Hospitalist, University of Minnesota, Mayo Building, 420 Delaware Street, SE, 6 Floor, Room D694, Minneapolis, MN 55455, United States.
Michael UsherDepartment of Medicine, Division of General Internal Medicine, Assistant Professor of Medicine, Hospitalist, University of Minnesota, Mayo Building, 420 Delaware Street, SE, 6 Floor, Room D694, Minneapolis, MN 55455, United States.
Surbhi ShahDepartment of Hematology and oncology, Mayo Clinic, Arizona, United States.
Christopher J TignanelliDepartment of Surgery, University of Minnesota, Minneapolis, MN, United States.
Ryan T DemmerDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, United States.
University of Minnesota · USUniversity of Basel · CHMayo Clinic in Arizona · USUniversity of Minnesota Medical Center · US

Funding

Health Information Exchange Utilization and Inter-hospital Transfer OutcomesR01HS026732 · AHRQ · UNIVERSITY OF MINNESOTA · PI USHER, MICHAEL G. · 2019 to 2022
$1.3M
AHRQ HHS R01 HS026732
6 · The paper itself

Abstract

backgroundCoronavirus disease 2019 (COVID-19) is associated with a hypercoagulable state. Limited data exist informing the relationship between anticoagulation therapy and risk for COVID-19 related hospitalization and mortality.

methodsWe evaluated all patients over the age of 18 diagnosed with COVID-19 in a prospective cohort study from March 4th to August 27th, 2020 among 12 hospitals and 60 clinics of M Health Fairview system (USA). We investigated the relationship between (1) 90-day anticoagulation therapy among outpatients before COVID-19 diagnosis and the risk for hospitalization and mortality and (2) Inpatient anticoagulation therapy and mortality risk.

findingsOf 6195 patients, 598 were immediately hospitalized and 5597 were treated as outpatients. The overall case-fatality rate was 2•8% (

interpretationOutpatients with COVID-19 who were on outpatient anticoagulation at the time of diagnosis experienced a 43% reduced risk of hospitalization. Failure to initiate anticoagulation upon hospitalization or maintaining outpatient anticoagulation in hospitalized COVID-19 patients was associated with increased mortality risk.

fundingNo funding was obtained for this study.

Indexed as

ACEi, angiotensin-converting enzyme inhibitorsAnticoagulationARBs, angiotensin receptor blockersCI, confidence intervalsCKD, chronic kidney diseaseCO2, carbon dioxideCOPD, chronic obstructive pulmonary diseaseCOVID-19COVID-19, coronavirus disease 2019D-dimerDIC, disseminated intravascular coagulationDOAC, direct oral anticoagulantEHR, electronic health recordsEMR, electronic medical recordsHCT, hematocritHIT, heparin-induced thrombocytopeniaHospitalizationHR, hazard ratioInpatientIPAC, inpatient anticoagulation therapyIRB, institutional review boardmg/dl, milligram per deciliterMI, prior myocardial infarctionMortality(n), numberOPAC, outpatient persistent anticoagulation therapyOutpatient%, percentageRDW, red blood cell distribution widthrt-PCR, reverse transcriptase-polymerase chain reactionSARS-CoV-2, severe Acute Respiratory Syndrome Coronavirus-2SBP-min, minimum systolic blood pressureSBP, systolic blood pressureSD, standard deviationsSE, standard errorsSpO2-min, minimum oxygen saturationT1DM, type 1 diabetes mellitusT2DM, type 2 diabetes mellitusVTE, venous thromboembolismWBC, white blood cell

Identifiers

PMID34585129
PMCPMC8461367
OpenAlexW3204787319

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.