ArticleEClinicalMedicine2021
Serum Chloride and Mortality in patients on continuous ambulatory peritoneal dialysis: A multi-center retrospective study.
Article in EClinicalMedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Association of serum chloride concentration with the risk of major adverse cardiovascular events in patients undergoing peritoneal dialysis: the Fukuoka peritoneal dialysis registry (F-PDR).Clinical and experimental nephrology · 2026Article
- Association of Serum Chloride Concentration With All-Cause and Cardiovascular Mortality in Patients Undergoing Peritoneal Dialysis: The Fukuoka Peritoneal Dialysis Registry.Kidney medicine · 2026Article
- Review
- A combined nutritional index and mortality in patients with peritoneal dialysis.Renal failure · 2025Article
- The combination of left ventricular ejection fraction and end-diastolic diameter and outcomes in peritoneal dialysis patients: a multicenter retrospective study.Renal failure · 2025Article
- Clinical uremic syndrome scores and mortality in peritoneal dialysis: a multi-center retrospective study.Scientific reports · 2025Article
- Serum sodium to chloride ratio and mortality on continuous ambulatory peritoneal dialysis: a multicenter retrospective study.MedComm · 2025Article
- C-Reactive Protein-to-Serum Chloride Ratio: A Novel Marker of All-Cause Mortality in Maintenance Haemodialysis Patients.Medicina (Kaunas, Lithuania) · 2024Article
- Association between systemic immune inflammation Index and all-cause mortality in incident peritoneal dialysis-treated CKD patients: a multi-center retrospective cohort study.BMC nephrology · 2024Article
- L-Shaped Association of Serum Chloride Level With All-Cause and Cause-Specific Mortality in American Adults: Population-Based Prospective Cohort Study.JMIR public health and surveillance · 2023Article
- Total cholesterol and mortality in peritoneal dialysis: a retrospective cohort study.BMC nephrology · 2023Article
- Creatine Kinase and Mortality in Peritoneal Dialysis.Frontiers in cardiovascular medicine · 2022Article
- Low-Density Lipoprotein Cholesterol and Mortality in Peritoneal Dialysis.Frontiers in nutrition · 2022Article
- Albumin to Total Cholesterol Ratio and Mortality in Peritoneal Dialysis.Frontiers in medicine · 2022Article
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Authors and funding
8 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLower serum chloride is associated with a higher risk of mortality in the general population. However, the association has received little attention in peritoneal dialysis patients. The study aimed to examine the association between serum chloride and mortality in peritoneal dialysis patients.
methodsIn this multicenter retrospective cohort study, 2376 Chinese incident patients on peritoneal dialysis between January 1, 2005, and March 31, 2020, were included. Patients were grouped according to quartiles of serum chloride at baseline. The associations of baseline serum chloride and cardiovascular mortality and all-cause mortality were evaluated using cause-specific hazards models.
findingsOf 2376 patients, the mean age was 45.9 (45.3,46.5) years, 50.1% of patients were men. The median serum chloride levels were 103.0 (99.0,106.9) mmol/L. During 9304.5 person-years of follow-up, 462 patients died, of which 235 deaths were caused by cardiovascular disease. The highest quartile group was associated with a higher risk of cardiovascular mortality (adjusted hazards ratio [HR], 2.95; 95% confidence interval [CI], 1.80 to 4.95) and all-cause mortality (adjusted HR, 2.03; 95% CI, 1.45 to 2.83) compared with the lowest quartile. The similar trend was also found when serum chloride levels were deal as continuous variable.
interpretationHigher serum chloride at the initial of peritoneal dialysis was associated with a higher risk of cardiovascular mortality and all-cause mortality in patients on peritoneal dialysis.
fundingThis work was supported by Shanghai Municipal Health Commission (2019SY018).
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