ArticleAnnals of gastroenterological surgery2021
Effect of TU-100 on Peyer's patches in a bacterial translocation rat model.
Article in Annals of gastroenterological surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 4 citations in OpenAlex.
- Barrier Perturbation in Porcine Peyer's Patches by Tumor Necrosis Factor is Associated With a Dysregulation of Claudins.Frontiers in physiology · 2022Article
- Effect of TU-100 on Peyer's patches in a bacterial translocation rat model.Annals of gastroenterological surgery · 2021Article
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10 authors at 1 institution in 1 country.
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Abstract
backgroundDaikenchuto (TU-100), a Japanese herbal medicine, is widely used for various gastrointestinal diseases. We have previously reported that TU-100 suppresses CPT-11-induced bacterial translocation (BT) by maintaining the diversity of the microbiome. In this study we show that TU-100 modulates the immune response during BT by inducing PD-1 expression in Peyer's patches.
methodsEighteen male Wistar rats were divided into four groups: a control group; a control + TU-100 group, given TU-100 1000 mg/kg orally for 5 d; a BT group, given CPT-11 250 mg/kg intra-peritoneal for 2 d; and a TU-100 group, given TU-100 1000 mg/kg orally for 5 d with CPT-11 250 mg/kg intra-peritoneal on days 4 and 5.
resultsThe size of Peyer's patch was significantly bigger in the BT group compared to the control group (9.0 × 104 µm
conclusionTU-100 may have a protective effect against BT through PD-1 expression in Peyer's patch.
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