ArticleNeurobiology of stress2021
From genetics to systems biology of stress-related mental disorders.
Article in Neurobiology of stress, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Identifying differential interactions of potentially traumatic experiences with genetic risk for posttraumatic stress disorder.European journal of psychotraumatology · 2026Article
- Childhood adversity and trajectories of health and quality of life in Australian children and adolescents: a latent class analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- Post-traumatic stress disorder.Nature reviews. Disease primers · 2026Review
- Trauma exposure, PTSD, and methylation of the blood brain barrier claudin-5 gene.Psychoneuroendocrinology · 2026Article
- Trauma Exposure, PTSD, and Methylation of the Blood Brain Barrier Claudin-5 Gene.medRxiv : the preprint server for health sciences · 2025Article
- Shared genetic architecture of posttraumatic stress disorder with cardiovascular imaging, risk, and diagnoses.Nature communications · 2025Article
- Post-traumatic stress disorder: evolving conceptualization and evidence, and future research directions.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025Article
- Regulation of Stress-Induced Immunosuppression in the Context of Neuroendocrine, Cytokine, and Cellular Processes.Biology · 2025Review
- Article
- Genetics of posttraumatic stress disorder and cardiovascular conditions using Life's Essential 8, Electronic Health Records, and Heart Imaging.medRxiv : the preprint server for health sciences · 2024Article
- Systems biology dissection of PTSD and MDD across brain regions, cell types, and blood.Science (New York, N.Y.) · 2024Article
- The cortisol switch between vulnerability and resilience.Molecular psychiatry · 2024Review
- Differences in genetic correlations between posttraumatic stress disorder and alcohol-related problems phenotypes compared to alcohol consumption-related phenotypes.Psychological medicine · 2023Article
- Genetics and epigenetics of stress: New avenues for an old concept.Neurobiology of stress · 2023Article
- Influence of Sports Training in Foothills on the Professional Athlete's Immunity.Sports (Basel, Switzerland) · 2023Article
- Psychological and biological mechanisms linking trauma with cardiovascular disease risk.Translational psychiatry · 2023Review
- Involvement of a BH3-only apoptosis sensitizer gene Blm-s in hippocampus-mediated mood control.Translational psychiatry · 2022Article
- Brain mineralocorticoid and glucocorticoid receptor balance in neuroendocrine regulation and stress-related psychiatric etiopathologies.Current opinion in endocrine and metabolic research · 2022Review
- Mineralocorticoid receptor and glucocorticoid receptor work alone and together in cell-type-specific manner: Implications for resilience prediction and targeted therapy.Neurobiology of stress · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Many individuals will be exposed to some form of traumatic stress in their lifetime which, in turn, increases the likelihood of developing stress-related disorders such as post-traumatic stress disorder (PTSD), major depressive disorder (MDD) and anxiety disorders (ANX). The development of these disorders is also influenced by genetics and have heritability estimates ranging between ∼30 and 70%. In this review, we provide an overview of the findings of genome-wide association studies for PTSD, depression and ANX, and we observe a clear genetic overlap between these three diagnostic categories. We go on to highlight the results from transcriptomic and epigenomic studies, and, given the multifactorial nature of stress-related disorders, we provide an overview of the gene-environment studies that have been conducted to date. Finally, we discuss systems biology approaches that are now seeing wider utility in determining a more holistic view of these complex disorders.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.