ReviewTranslational pediatrics2021
Impacts of prenatal diagnosis of congenital heart diseases on outcomes.
Review in Translational pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- A Systematic Review of Methods and Practice for Integrating Maternal, Fetal, and Child Health Outcomes, and Family Spillover Effects into Cost-Utility Analyses.PharmacoEconomics · 2024Pooled it
- AI-Driven Analysis of the Fetal Left Ventricular Outflow Tract: Diagnostic Value and Applications.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2026Article
- Prenatal parental mental health and neurodevelopment in children with congenital heart disease.Pediatric research · 2026Review
- Role of Prenatal Echocardiographic Diagnosis in Early Postnatal Management of Congenital Heart Disease at a Single Center Without Neonatal Cardiac Surgery.Yonago acta medica · 2026Article
- Enhancing Fetal Cardiac Care: Addressing Unwarranted Variation in Prenatal Congenital Heart Disease Detection and Counseling.Current cardiology reports · 2026Review
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- Article
- Challenges Faced by Healthcare Professionals in Screening Newborns for Congenital Heart Defects in Pakistan.International journal of neonatal screening · 2025Article
- Associations of Physician Perspectives, Personal Choices, and Counseling for Severe Congenital Heart Defects.Prenatal diagnosis · 2025Article
- Impact of a Standardised Fetal Cardiac Screening Programme on Antenatal Detection Rates of Transposition of the Great Arteries.Australasian journal of ultrasound in medicine · 2025Article
- Prenatal diagnosis mediates the relationship between disease complexity and intervention timing for congenital heart defects.Pregnancy (Hoboken, N.J.) · 2025Article
- School Readiness in Preschool-Age Children with Critical Congenital Heart Disease.Pediatric cardiology · 2025Article
- Evaluation of Integrated Service Strategy Based on Diagnosis of Duct-Dependent Congenital Heart Disease and Neonatal Mortality Data Analysis - Beijing, China, 2021-2022.China CDC weekly · 2025Article
- Chromosomal analysis and short-term outcome of prenatally diagnosed congenital heart disease.Scientific reports · 2025Article
- Keeping the Ductus Arteriosus Patent: Current Strategy and Perspectives.Diagnostics (Basel, Switzerland) · 2025Review
- Analysis of fatal congenital anomalies among pregnant women at Saudi Arabia using ultrasonography.Bioinformation · 2025Article
- Pulse Oximetry Screening for Critical Congenital Heart Defects: Effectiveness and Implementation across Clinical Settings.Cardiology and cardiovascular medicine · 2025Article
- The Italian Perinatal Surveillance System SPItOSS: insights from Confidential Enquiries.Italian journal of pediatrics · 2024Article
- Neonatal Mortality Disparities by Gestational Age in European Countries.JAMA network open · 2024Article
- Live-Birth Incidence of Isolated D-Transposition of Great Arteries-The Shift in Trends Due to Early Diagnosis.Diagnostics (Basel, Switzerland) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prenatal diagnosis of congenital heart diseases (CHD) is increasingly performed in developed countries. Still, the current impacts of prenatal diagnosis on fetal and neonatal outcomes remains unclear or contradictory. We will review here the different consequences of prenatal screening and of fetal echocardiography on different categories of outcomes. Increasing detection may lead to a reduced birth incidence of severe complex CHD through a high rate of termination of pregnancy but this trend is not universal. Conversely, one of the main impacts of prenatal diagnosis is to optimize perinatal care and to improve hard outcomes such as mortality. Indeed, decrease of neonatal mortality is inconsistently observed in transposition of the great arteries and is not shown in other defects. The reduction of perinatal morbidity is a new end-point to scrutinize but how to examine this impact is controversial in the neonatal period. The influence of the reduction of neonatal distress may modify neurodevelopmental outcomes and quality of survival. The risk stratification after a prenatal diagnosis of CHD helps to optimize the timing, mode, and site of management with the aim to improve outcomes. The anticipated care is tailored according to the type of CHD and expected initial physiology. However, the imprecision of prenatal diagnosis even in expert centers hampers this logical outcome. Prediction of the type of repair is theoretically possible but remains challenging in defects such as double outlet right ventricles or pulmonary atresia with ventricular septal defect. The cost of prenatal diagnosis or of its absence is still a matter of debate and policies have to be tailored to regional health systems. Finally, the impact on parents and siblings is a rarely explored outcome. Screening and echography of fetal heart are currently performed in developed countries but it is still too early to talk about fetal cardiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.