Evidence map›Paper›PMID 34584743›Full record

ArticleIUCrJ2021

Chasing the structural diversity of the transcription regulator

William Richardson, Gyun Won Kang, Hee Joong Lee, Kang Mu Kwon, Saron Kim, Hyo Jung Kim

Open access · goldAbstract read
In one paragraph

Article in IUCrJ, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Identification of Genes Encoded Toxin-Antitoxin System inInfectious disorders drug targets · 2024
    Article
  4. Focused Overview ofBiomimetics (Basel, Switzerland) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

William RichardsonCentre for Biomolecular Sciences, School of Pharmacy, University of Nottingham, Nottingham, United Kingdom.ORCID https://orcid.org/0000-0003-0674-4898
Gyun Won KangCollege of Pharmacy, Woosuk University, Wanju 55338, Republic of Korea.
Hee Joong LeeCollege of Pharmacy, Woosuk University, Wanju 55338, Republic of Korea.
Kang Mu KwonCollege of Pharmacy, Woosuk University, Wanju 55338, Republic of Korea.ORCID https://orcid.org/0000-0002-1160-3726
Saron KimCollege of Pharmacy, Woosuk University, Wanju 55338, Republic of Korea.
Hyo Jung KimCentre for Biomolecular Sciences, School of Pharmacy, University of Nottingham, Nottingham, United Kingdom.ORCID https://orcid.org/0000-0001-5214-3036
Woosuk University · KRUniversity of Nottingham · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transcription factors are the primary regulators of gene expression and recognize specific DNA sequences under diverse physiological conditions. Although they are vital for many important cellular processes, it remains unclear when and how transcription factors and DNA interact. The antitoxin from a toxin-antitoxin system is an example of negative transcriptional autoregulation: during expression of the cognate toxin it is suppressed through binding to a specific DNA sequence. In the present study, the antitoxin HigA2 from

Indexed as

crystal structureHigA2HigBAMycobacterium tuberculosisstructure determinationtoxin–antitoxin systemstranscription factorsX-ray crystallography

Identifiers

PMID34584743
PMCPMC8420761
OpenAlexW3196142271

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.