IL29 expression in gingival tissues of chronic periodontitis and aggressive periodontitis patients: An immunohistochemical analysis.

Zahra Alizadeh Tabari, Somayeh Hematzadeh, Forooz Keshani

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Article in Dental research journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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Zahra Alizadeh TabariDepartment of Periodontics, School of Dentistry , Qazvin University of Medical Sciences, Qazvin, Iran.

Somayeh HematzadehDepartment of Periodontics, School of Dentistry , Qazvin University of Medical Sciences, Qazvin, Iran.

Forooz KeshaniDepartment of Oral and Maxillofacial Pathology, Dental Research Center, Dental Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.

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6 · The paper itself

Abstract

backgroundInterleukin-29 (IL-29) is one of the cytokines which has immunomodulatory properties and might play a role in the pathogenesis of periodontal diseases. The aim of this study was an immunohistochemical analysis of IL-29 in gingival tissues of chronic and aggressive periodontitis. MATERIALS AND

methodsIn this cross-sectional study based on clinical evaluation and inclusion and exclusion criteria, 20 patients with generalized chronic periodontitis, 13 patients with generalized aggressive periodontitis, and 20 periodontally healthy individuals were enrolled. Gingival tissue samples were obtained during periodontal flap and crown lengthening surgery in periodontal patients and healthy individuals, respectively. Tissue samples were examined to determine the level of IL-29 expression by immunohistochemistry. The data were analyzed using SPSS and paired

resultsA total of 53 participants (34 females and 19 males) were enrolled in this study. IL-29 expression in the connective tissue of the patient groups was more than the healthy one (

conclusionAccording to the results of this study, IL-29 expression was increased in the gingival tissue of aggressive and chronic periodontitis. IL-29 local expression in aggressive periodontitis is higher than the chronic periodontitis and healthy groups, which could suggest the role of IL-29 in the etiopathogenesis of aggressive periodontitis.

Indexed as

Aggressive periodontitischronic periodontitiscytokinesImmunohistochemistryinterleukin-29

Identifiers

PMID34584644

PMCPMC8428285

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