Evidence map›Paper›PMID 34584616›Full record

ReviewOxidative medicine and cellular longevity2021

Nano-Derived Therapeutic Formulations with Curcumin in Inflammation-Related Diseases.

Cristina Quispe, Natália Cruz-Martins, Maria Letizia Manca, Maria Manconi, Oksana Sytar, Nataliia Hudz, Mariia Shanaida, Manoj Kumar, Yasaman Taheri, Miquel Martorell and 3 more

Abstract readReview
In one paragraph

Review in Oxidative medicine and cellular longevity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Trial
  2. Review
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  4. Therapeutic Potential of Plant Phenolic Acids Combating Cancer Drug Resistance.Recent advances in food, nutrition & agriculture · 2026
    Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
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  15. Review
  16. Ayurvedic and Chinese Herbs against Coronaviruses.Current pharmaceutical design · 2024
    Review
  17. Review
  18. Natural Ingredients to Improve Immunity.Pharmaceuticals (Basel, Switzerland) · 2023
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Cristina QuispeFacultad de Ciencias de la Salud, Universidad Arturo Prat, Avda. Arturo Prat 2120, Iquique 1110939, Chile.
Natália Cruz-MartinsFaculty of Medicine, University of Porto, Alameda Prof. Hernani Monteiro, Porto, Portugal.ORCID https://orcid.org/0000-0002-5934-5201
Maria Letizia MancaDepartment of Scienze della Vita e dell'Ambiente, Drug Science Division, University of Cagliari, 09124 Cagliari, Italy.
Maria ManconiDepartment of Scienze della Vita e dell'Ambiente, Drug Science Division, University of Cagliari, 09124 Cagliari, Italy.
Oksana SytarDepartment of Plant Physiology, Faculty of Agrobiology and Food Resources, Slovak University of Agriculture, 94976 Nitra, Slovakia.
Nataliia HudzDepartment of Drug Technology and Biopharmaceutics, Danylo Halytsky Lviv National Medical University, Pekarska 69, Lviv, Ukraine.ORCID https://orcid.org/0000-0002-2240-0852
Mariia ShanaidaDepartment of Pharmacognosy and Medical Botany, I. Horbachevsky Ternopil National Medical University, Voli 1, Ternopil, Ukraine.
Manoj KumarChemical and Biochemical Processing Division, ICAR-Central Institute for Research on Cotton Technology, Mumbai 400019, India.ORCID https://orcid.org/0000-0002-4192-6497
Yasaman TaheriPhytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0002-0836-236X
Miquel MartorellDepartment of Nutrition and Dietetics, Faculty of Pharmacy, and Centre for Healthy Living, University of Concepción, 4070386 Concepcion, Chile.ORCID https://orcid.org/0000-0003-3183-7623
Javad Sharifi-RadPhytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0002-7301-8151
Gianfranco PintusDepartment of Medical Laboratory Sciences, College of Health Sciences and Sharjah Institute for Medical Research, University of Sharjah, 22272 Sharjah, UAE.ORCID https://orcid.org/0000-0002-3031-7733
William C ChoDepartment of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong.ORCID https://orcid.org/0000-0003-4174-4586

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Due to its vast therapeutic potential, the plant-derived polyphenol curcumin is utilized in an ever-growing number of health-related applications. Here, we report the extraction methodologies, therapeutic properties, advantages and disadvantages linked to curcumin employment, and the new strategies addressed to improve its effectiveness by employing advanced nanocarriers. The emerging nanotechnology applications used to enhance CUR bioavailability and its targeted delivery in specific pathological conditions are collected and discussed. In particular, new aspects concerning the main strategic nanocarriers employed for treating inflammation and oxidative stress-related diseases are reported and discussed, with specific emphasis on those topically employed in conditions such as wounds, arthritis, or psoriasis and others used in pathologies such as bowel (colitis), neurodegenerative (Alzheimer's or dementia), cardiovascular (atherosclerosis), and lung (asthma and chronic obstructive pulmonary disease) diseases. A brief overview of the relevant clinical trials is also included. We believe the review can provide the readers with an overview of the nanostrategies currently employed to improve CUR therapeutic applications in the highlighted pathological conditions.

Indexed as

ArthritisBiological AvailabilityCurcuminDrug CarriersDrug StabilityHumansNanotechnologyNeurodegenerative DiseasesPlants, MedicinalCurcuminDrug Carriers

Identifiers

PMID34584616
PMCPMC8470924

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.