Evidence map›Paper›PMID 34584231›Full record

Observational studyEye (London, England)2022

Sensitivity and specificity of pseudocolor ultrawide field imaging in comparison to wide field fundus fluorescein angiography in detecting retinal neovascularization in diabetic retinopathy.

Swathy Haridas, Swati Indurkhya, Sailesh Kumar, Anantharaman Giridhar, Sobha Sivaprasad

Open access · bronzeAbstract readObservational Study
In one paragraph

Observational study in Eye (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Scanning laser ophthalmoscopy retroillumination: applications and illusions.International journal of retina and vitreous · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Swathy HaridasGiridhar Eye Institute, Cochin, India.
Swati IndurkhyaGiridhar Eye Institute, Cochin, India.
Sailesh KumarGiridhar Eye Institute, Cochin, India.
Anantharaman GiridharGiridhar Eye Institute, Cochin, India. giridhareye@gmail.com.ORCID 0000-0002-7126-4885
Sobha SivaprasadNIHR Moorfields Biomedical Research Centre, Moorfields Eye Hospital, 162 City Road, London, EC1V2PD, UK.ORCID 0000-0001-8952-0659
NIHR Moorfields Biomedical Research Centre · GBSeva Mandir · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the diagnostic accuracy of ultrawide pseudocolor retinal photography (pseudocolor UWF) compared to wide field fundus fluorescein angiography (WFFFA) in the detection of retinal neovascularization (NV) and NV of the disc (NVD) in patients with diabetic retinopathy (DR).

designDiagnostic accuracy observational study evaluating pseudocolor UWF as the index test. The reference standard was WFFFA.

settingSingle retinal centre in India.

participantsPeople with severe non-proliferative DR (sNPDR), early proliferative DR (ePDR) or high-risk proliferative DR (HR PDR).

main outcome measuresSensitivity and specificity of pseudocolor UWF in the detection of NV.

resultsA total of 176 eyes of 94 subjects with sNPDR, ePDR or HR PDR underwent pseudocolor UWF and WFFFA. The sensitivity and specificity of pseudocolor UWF in detecting NVE were 92.5% (95% CI 86.2-96.5) and 81% (95% CI 64.8-92.0), respectively, with moderate interobserver agreement of 0.722 (p value 0.001). The positive predictive value and negative predictive value were 83.0 (71.4-90.5) and 91.5 (84.9-95.3), respectively.

conclusionCompared to WFFFA as the gold standard, pseudocolor UWF has high sensitivity and specificity in detection of NV in all retinal quadrants and NVD. Therefore, pseudocolor UWF may be used as a non-invasive tool for screening and managing DR.

Indexed as

Diabetes MellitusDiabetic RetinopathyRetinal NeovascularizationFluorescein AngiographyHumansRetinaRetinal VesselsSensitivity and Specificity

Identifiers

PMID34584231
PMCPMC9499994
OpenAlexW3204596489

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.