ArticleMolecular psychiatry2021
Neutral sphingomyelinase mediates the co-morbidity trias of alcohol abuse, major depression and bone defects.
Open access · hybridAbstract read
In one paragraph
Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 9% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Self-management with alcohol over lifespan: psychological mechanisms, neurobiological underpinnings, and risk assessment.Molecular psychiatry · 2023Pooled it
- The role of sphingolipids in major depressive disorder and associated cognitive impairment: interactions with monoaminergic signaling, neuroinflammation, and neurogenesis.Molecular psychiatry · 2026Review
- Integration of resting-state and stimulus-fMRI uncovers reduced network flexibility in post-surgical pain.Scientific reports · 2026Article
- Sphingolipids in Emotional Well-Being.Journal of neurochemistry · 2026Review
- The Bone-Brain Axis: Novel Insights into the Bidirectional Crosstalk in Depression and Osteoporosis.Biomolecules · 2026Review
- Acid sphingomyelinase activity suggests a new antipsychotic pharmaco-treatment strategy for schizophrenia.Molecular psychiatry · 2025Article
- Exercise improves depressive-like behavior in adolescent mice by regulating sphingosine and ceramide metabolism through microglial CerS1.Communications biology · 2025Article
- Associations between monocyte to HDL-C ratio and lumbar bone mineral density in alcohol dependent individuals with depression.Scientific reports · 2025Article
- Hepatic sphingomyelin phosphodiesterase 3 promotes steatohepatitis by disrupting membrane sphingolipid metabolism.Cell metabolism · 2025Article
- Pharmacological and resting state fMRI reveal Osteocalcin's effects on mouse brain regions with high Gpr37 and Gpr158 expression.Scientific reports · 2025Article
- Compromising Tyrosine Hydroxylase Function Extends and Blunts the Temporal Profile of Reinforcement by Dopamine Neurons inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Unveiling the multifaceted antiproliferative efficacy ofRSC advances · 2024Article
- Serotonin Signaling through Lipid Membranes.ACS chemical neuroscience · 2024Review
- Masculine depression and its problem behaviors: use alcohol and drugs, work hard, and avoid psychiatry!European archives of psychiatry and clinical neuroscience · 2024Article
- Trimetazidine Alleviates Bleomycin-Induced Pulmonary Fibrosis by Targeting the Long Noncoding RNA CBR3-AS1-Mediated miRNA-29 and Resistin-Like Molecule alpha 1: Deciphering a Novel Trifecta Role of LncRNA CBR3-AS1/miRNA-29/FIZZ1 Axis in Lung Fibrosis.Drug design, development and therapy · 2024Article
- Synthesis and antiproliferative evaluation of novel 3,5,8-trisubstituted coumarins against breast cancer.Future medicinal chemistry · 2024Article
- Article
- Article
- Behavioural effects of APH199, a selective dopamine D4 receptor agonist, in animal models.Psychopharmacology · 2023Article
- Characterization of a Neutral Sphingomyelinase Activity in Human Serum and Plasma.International journal of molecular sciences · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
58 authors at 14 institutions in 9 countries.
Liubov S KalinichenkoDepartment of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Christiane MühleDepartment of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.ORCID http://orcid.org/0000-0001-7517-9154
Tianye JiaThe Centre for Population Neuroscience and Stratified Medicine (PONS), ISTBI, Fudan University, Shanghai, China.
Felix AnderheidenDepartment of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Maria DatzDepartment of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Anna-Lisa EberleDepartment of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.ORCID http://orcid.org/0000-0001-6657-5796
Volker EulenburgDepartment for Anesthesiology and Intensive Care, Faculty of Medicine, University of Leipzig, Leipzig, Germany.
Jonas GranzowDepartment of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Martin HoferDepartment of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Julia HohenschildDepartment of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Sabine E HuberDepartment of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Stefanie KämpfDepartment of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Georgios KogiasDepartment of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Laura LacatusuDepartment of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Charlotte LugmairDepartment of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Stephen Mbu TakuDepartment of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Doris MeixnerDepartment of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Nina TeschDepartment of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Marc PraetnerDepartment of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Cosima RheinDepartment of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Christina SauerDepartment of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.ORCID http://orcid.org/0000-0002-5073-9693
Jessica ScholzDepartment of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Franziska UlrichDepartment of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Florian ValentaDepartment of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Esther WeigandDepartment of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Markus WernerDepartment of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Nicole TayThe Centre for Population Neuroscience and Stratified Medicine (PONS), ISTBI, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0002-1307-408X
Conor J Mc VeighSchool of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland.
Jana HaaseSchool of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland.ORCID http://orcid.org/0000-0002-5949-8355
An-Li WangCenter for Behavioral Neuroscience, Institute of Experimental Psychology, University of Düsseldorf, Düsseldorf, Germany.
Laila Abdel-HafizCenter for Behavioral Neuroscience, Institute of Experimental Psychology, University of Düsseldorf, Düsseldorf, Germany.
Joseph P HustonCenter for Behavioral Neuroscience, Institute of Experimental Psychology, University of Düsseldorf, Düsseldorf, Germany.
Irena SmagaDepartment of Drug Addiction Pharmacology, Maj Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.
Malgorzata FrankowskaDepartment of Drug Addiction Pharmacology, Maj Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.ORCID http://orcid.org/0000-0002-6646-6140
Malgorzata FilipDepartment of Drug Addiction Pharmacology, Maj Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.
Anbarasu LourdusamyDivision of Child Health, Obstetrics and Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK.ORCID http://orcid.org/0000-0002-1978-6301
Philipp KirchnerInstitute of Human Genetics, Friedrich-Alexander-University of Erlangen-Nuremberg (FAU), Erlangen, Germany.
Arif B EkiciInstitute of Human Genetics, Friedrich-Alexander-University of Erlangen-Nuremberg (FAU), Erlangen, Germany.ORCID http://orcid.org/0000-0001-6099-7066
Lena M MarxDepartment of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Neeraja Puliparambil SureshDepartment of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Renato FrischknechtDepartment of Biology, Animal Physiology, Friedrich-Alexander-University of Erlangen-Nürnberg, Erlangen, Germany.
Anna FejtovaDepartment of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.ORCID http://orcid.org/0000-0002-1815-4409
Essa M SaiedInstitute for Chemistry, Humboldt University, Berlin, Germany.
Christoph ArenzInstitute for Chemistry, Humboldt University, Berlin, Germany.ORCID http://orcid.org/0000-0001-7613-9437
Aline BozecDepartment of Internal Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-University of Erlangen- Nürnberg, Erlangen, Germany.ORCID http://orcid.org/0000-0001-8174-2118
Isabel WankDepartment of Experimental and Clinical Pharmacology and Toxicology, Emil Fischer Center, Friedrich-Alexander-University of Erlangen-Nuremberg (FAU), Erlangen, Germany.
Silke KreitzDepartment of Experimental and Clinical Pharmacology and Toxicology, Emil Fischer Center, Friedrich-Alexander-University of Erlangen-Nuremberg (FAU), Erlangen, Germany.
Andreas HessDepartment of Experimental and Clinical Pharmacology and Toxicology, Emil Fischer Center, Friedrich-Alexander-University of Erlangen-Nuremberg (FAU), Erlangen, Germany.
Tobias BäuerlePreclinical Imaging Platform Erlangen, Institute of Radiology, University Hospital Erlangen, Erlangen, Germany.
Maria Dolores LedesmaCentro Biologia Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain.ORCID http://orcid.org/0000-0002-5679-6891
Daniel N MitroiCentro Biologia Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain.
André M MirandaLife and Health Sciences Research Institute (ICVS), School of Medicine, Campus Gualtar, University of Minho, Braga, Portugal.
Tiago G OliveiraLife and Health Sciences Research Institute (ICVS), School of Medicine, Campus Gualtar, University of Minho, Braga, Portugal.
Erich GulbinsDepartment of Molecular Biology, University of Duisburg-Essen, Essen, Germany.
Bernd LenzDepartment of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.ORCID http://orcid.org/0000-0001-6086-0924
Gunter Schumann *The Centre for Population Neuroscience and Stratified Medicine (PONS), ISTBI, Fudan University, Shanghai, China.
Johannes Kornhuber *Department of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.ORCID http://orcid.org/0000-0002-8096-3987
Christian P Müller *Department of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany. Christian.Mueller@uk-erlangen.de.ORCID http://orcid.org/0000-0002-5325-9900
Friedrich-Alexander-Universität Erlangen-Nürnberg · DEHeinrich Heine University Düsseldorf · DEMaj Institute of Pharmacology · PLCentro de Biología Molecular Severo Ochoa · ESHumboldt-Universität zu Berlin · DEKing's College London · GBUniversity College Dublin · IEUniversity of Minho · PTFudan University · CNLeipzig University · DEUniversitätsklinikum Erlangen · DEUniversiti Sains Malaysia · MYUniversity of Duisburg-Essen · DEUniversity of Nottingham · GB
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mental disorders are highly comorbid and occur together with physical diseases, which are often considered to arise from separate pathogenic pathways. We observed in alcohol-dependent patients increased serum activity of neutral sphingomyelinase. A genetic association analysis in 456,693 volunteers found associations of haplotypes of SMPD3 coding for NSM-2 (NSM) with alcohol consumption, but also with affective state, and bone mineralisation. Functional analysis in mice showed that NSM controls alcohol consumption, affective behaviour, and their interaction by regulating hippocampal volume, cortical connectivity, and monoaminergic responses. Furthermore, NSM controlled bone-brain communication by enhancing osteocalcin signalling, which can independently supress alcohol consumption and reduce depressive behaviour. Altogether, we identified a single gene source for multiple pathways originating in the brain and bone, which interlink disorders of a mental-physical co-morbidity trias of alcohol abuse-depression/anxiety-bone disorder. Targeting NSM and osteocalcin signalling may, thus, provide a new systems approach in the treatment of a mental-physical co-morbidity trias.
Indexed as
AlcoholismBone DiseasesMajor Depressive DisorderSphingomyelin PhosphodiesteraseAnimalsComorbidityHumansMiceMorbiditySMPD3 protein, humanSmpd3 protein, mouseSphingomyelin Phosphodiesterase
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.