Evidence map›Paper›PMID 34584165›Full record

ArticleScientific reports2021

Impact of smoking, COPD and comorbidities on the mortality of COVID-19 patients.

Donato Lacedonia, Giulia Scioscia, Carla Santomasi, Paolo Fuso, Giovanna Elisiana Carpagnano, Andrea Portacci, Franco Mastroianni, Giovanni Larizza, Eugenio Sabato, Emanuela Profilo and 3 more

Abstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. COVID-19 in Patients with Chronic Lung Disease.Clinics in chest medicine · 2023
    Review
  10. The immunogenetics of COVID-19.Immunogenetics · 2023
    Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Donato LacedoniaRespiratory Diseases Unit, Department of Medical and Surgical Sciences, "Policlinico Riuniti" University Hospital, University of Foggia, Foggia, Italy.
Giulia SciosciaRespiratory Diseases Unit, Department of Medical and Surgical Sciences, "Policlinico Riuniti" University Hospital, University of Foggia, Foggia, Italy.
Carla SantomasiRespiratory Diseases Unit, Cardio-Thoracic Department, "Policlinico di Bari" University Hospital, University of Bari "Aldo Moro", Bari, Italy. carlasantomasi@gmail.com.
Paolo FusoRespiratory Diseases Unit, Department of Medical and Surgical Sciences, "Policlinico Riuniti" University Hospital, University of Foggia, Foggia, Italy.
Giovanna Elisiana CarpagnanoRespiratory Diseases Unit, Cardio-Thoracic Department, "Policlinico di Bari" University Hospital, University of Bari "Aldo Moro", Bari, Italy.
Andrea PortacciRespiratory Diseases Unit, Cardio-Thoracic Department, "Policlinico di Bari" University Hospital, University of Bari "Aldo Moro", Bari, Italy.
Franco MastroianniInternal Medicine COVID Unit, "F. Miulli" General Hospital, Acquaviva delle Fonti, 70021, Bari, Italy.
Giovanni LarizzaInternal Medicine COVID Unit, "F. Miulli" General Hospital, Acquaviva delle Fonti, 70021, Bari, Italy.
Eugenio Sabato"Antonio Blasi" Respiratory Diseases Unit, "A. Perrino" P.O., 72100, Brindisi, Italy.
Emanuela Profilo"Antonio Blasi" Respiratory Diseases Unit, "A. Perrino" P.O., 72100, Brindisi, Italy.
Emanuela RestaTranslational Medicine and Health System Management, University of Foggia, Foggia, Italy.
Maria Pia Foschino BarbaroRespiratory Diseases Unit, Department of Medical and Surgical Sciences, "Policlinico Riuniti" University Hospital, University of Foggia, Foggia, Italy.
Onofrio RestaRespiratory Diseases Unit, Cardio-Thoracic Department, "Policlinico di Bari" University Hospital, University of Bari "Aldo Moro", Bari, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prognosis of the coronavirus disease 2019 (COVID-19) patients is variable and depends on several factors. Current data about the impact of chronic obstructive pulmonary disease (COPD) and smoking on the clinical course of COVID-19 are still controversial. This study evaluated the prevalence and the prognosis of COPD patients and smokers in a cohort of 521 patients admitted to four intermediate Respiratory Intensive Care Units (Puglia, Italy) with respiratory failure due to COVID-19 pneumonia. The prevalence of COPD and current smokers was 14% and 13%, respectively. COPD patients had a higher 30-day all-cause mortality than non-COPD patients. Former smokers compared to never smokers and current smokers had higher 30-day all-cause mortality. COPD patients and former smokers had more comorbidities. This study described the prevalence and the outcomes of COPD patients and smokers in a homogenous cohort of COVID-19 patients. The study showed that the prevalence of COPD and current smokers was not high, suggesting that they were not at increased risk of getting the infection. However, when SARS-CoV-2 infection occurred, COPD patients and former smokers were those with the highest all-cause mortality, which seemed to be mainly related to the presence of comorbidities and not to COPD and smoking itself.

Indexed as

ComorbidityCOVID-19PrognosisPulmonary Disease, Chronic ObstructiveAgedCohort StudiesHospitalizationHumansItalyMaleMiddle AgedMortalityPrevalenceRisk FactorsSmoking

Identifiers

PMID34584165
PMCPMC8478875

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.