Observational studyScientific reports2021
Maternal pre-pregnancy BMI associates with neonate local and distal functional connectivity of the left superior frontal gyrus.
Observational study in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Associations between maternal adiposity during pregnancy and neonatal brain cortical development.NeuroImage · 2026Article
- Functional brain connectivity from the fetal period through infancy: A narrative review of resting-state fMRI studies.Developmental cognitive neuroscience · 2026Review
- Maternal obesity and the embryonic rewiring of feeding circuits: Beyond the hypothalamus.Molecular metabolism · 2026Review
- Investigating the influence of maternal prenatal BMI and perinatal depressive symptoms on neonatal brain network dynamics.Pediatric research · 2026Article
- Infant subcortical brain volumes associated with maternal obesity and diabetes: a large multicohort human study.BMC medicine · 2026Article
- Associations of Maternal Pre-Pregnancy BMI With Frontostriatal Connectivity in Young Children.Pediatric obesity · 2026Article
- From Cradle to Early-Life Sleep: A Bibliometric Analysis of Global Research on Neonatal Sleep.Nature and science of sleep · 2026Article
- Maternal Overweight and Obesity Alter Neurodevelopmental Trajectories During the First Year of Life: Findings from the OBESO Cohort.Children (Basel, Switzerland) · 2025Article
- Current states in understanding oligodendroglia-mediated neurological issues in neurofibromatosis type 1 (NF1).Acta neuropathologica communications · 2025Review
- Pre- and postnatal maternal depressive symptoms associated with local connectivity of the left amygdala in 5-year-olds.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Pre-pregnancy overweight or obesity moderates the association between prenatal maternal depressive symptoms and infant cord blood omega-3 levels.BMC pregnancy and childbirth · 2024Article
- Fetal cortical development and neurosonographic findings in obese pregnant women: a case control study from a tertiary hospital.Archives of gynecology and obstetrics · 2024Article
- Resistance Training Increases White Matter Density in Frail Elderly Women.Journal of clinical medicine · 2023Article
- Maternal pre-pregnancy obesity affects the uncinate fasciculus white matter tract in preterm infants.Frontiers in pediatrics · 2023Article
- Maternal psychological distress associates with alterations in resting-state low-frequency fluctuations and distal functional connectivity of the neonate medial prefrontal cortex.The European journal of neuroscience · 2023Article
- Maternal sensitivity at the age of 8 months associates with local connectivity of the medial prefrontal cortex in children at 5 years of age.Frontiers in neuroscience · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Maternal obesity/overweight during pregnancy has reached epidemic proportions and has been linked with adverse outcomes for the offspring, including cognitive impairment and increased risk for neuropsychiatric disorders. Prior neuroimaging investigations have reported widespread aberrant functional connectivity and white matter tract abnormalities in neonates born to obese mothers. Here we explored whether maternal pre-pregnancy adiposity is associated with alterations in local neuronal synchrony and distal connectivity in the neonate brain. 21 healthy mother-neonate dyads from uncomplicated pregnancies were included in this study (age at scanning 26.14 ± 6.28 days, 12 male). The neonates were scanned with a 6-min resting-state functional magnetic resonance imaging (rs-fMRI) during natural sleep. Regional homogeneity (ReHo) maps were computed from obtained rs-fMRI data. Multiple regression analysis was performed to assess the association of pre-pregnancy maternal body-mass-index (BMI) and ReHo. Seed-based connectivity analysis with multiple regression was subsequently performed with seed-ROI derived from ReHo analysis. Maternal adiposity measured by pre-pregnancy BMI was positively associated with neonate ReHo values within the left superior frontal gyrus (SFG) (FWE-corrected p < 0.005). Additionally, we found both positive and negative associations (p < 0.05, FWE-corrected) for maternal pre-pregnancy BMI and seed-based connectivity between left SFG and prefrontal, amygdalae, basal ganglia and insular regions. Our results imply that maternal pre-pregnancy BMI associates with local and distal functional connectivity within the neonate left superior frontal gyrus. These findings add to the evidence that increased maternal pre-pregnancy BMI has a programming influence on the developing neonate brain functional networks.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.