ArticleNPJ Parkinson's disease2021
Eight-hours conventional versus adaptive deep brain stimulation of the subthalamic nucleus in Parkinson's disease.
Article in NPJ Parkinson's disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 39 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Adaptive deep brain stimulation for Parkinson's disease: looking back at the past decade on motor outcomes.Journal of neurology · 2023Pooled it
- Adaptive deep brain stimulation for dynamic gait control in Parkinson's disease: a randomized feasibility trial.Nature medicine · 2026Trial
- Stimulation and Medication Effects on Subthalamic Nucleus Beta-Band Power in Parkinson's Disease: Implications for Adaptive Deep Brain Stimulation.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Local Field Potential Recordings Using Deep Brain Stimulation: A Practical Workflow and Open-Source Signal Processing Pipeline.Brain topography · 2026Article
- Adaptive Deep Brain Stimulation for Parkinson's Disease: Navigating the Roadblocks to Clinical Implementation.Movement disorders : official journal of the Movement Disorder Society · 2026Review
- Cognitive trajectories in Parkinson's disease patients, a review on the impact of subthalamic deep brain stimulation (STN-DBS) and emerging adaptive strategies.Translational psychiatry · 2026Review
- Review
- Electrographic cue-reactivity co-localizes with accumbens deep brain stimulation in a case of opioid use disorder.Nature communications · 2026Article
- Excessive daytime sleepiness in parkinsonism is associated with cortical and basal ganglia beta oscillatory activity.Communications biology · 2026Article
- Local field potential biomarkers for adaptive deep brain stimulation in Parkinson's disease: A scoping review.Surgical neurology international · 2026Review
- Prediction of Pathological Subthalamic Nucleus Beta Burst Occurrence in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Cognitive effects of adaptive deep brain stimulation in Parkinson's disease: stability without risk.European journal of medical research · 2025Article
- Adaptive deep brain stimulation timed to gait phase improves walking in Parkinson's disease.medRxiv : the preprint server for health sciences · 2025Article
- Delay suppression control of β-oscillations: a proposal for dual-target adaptive deep brain stimulation on STN-GPe network model.Biological cybernetics · 2025Article
- Patient, target, device, and program selection for DBS in Parkinson's disease: advancing toward precision care.NPJ Parkinson's disease · 2025Review
- Will adaptive deep brain stimulation for Parkinson's disease become a real option soon? A Delphi consensus study.NPJ Parkinson's disease · 2025Article
- Could adaptive deep brain stimulation treat freezing of gait in Parkinson's disease?Journal of neurology · 2025Review
- Master classes of the tenth international brain-computer interface meeting: showcasing the research of BCI trainees.Journal of neural engineering · 2025Article
- Evaluation of the therapeutic effect of adaptive deep brain stimulation on motor symptoms and sleep disturbances in Parkinson's disease and construction of a response prediction model.Frontiers in neurology · 2025Article
- Harnessing the sensing and stimulation function of deep brain-machine interfaces: a new dawn for overcoming substance use disorders.Translational psychiatry · 2024Review
Corrections and comments
- Erratum issued
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study compares the effects on motor symptoms between conventional deep brain stimulation (cDBS) and closed-loop adaptive deep brain stimulation (aDBS) in patients with Parkinson's Disease. The aDBS stimulation is controlled by the power in the beta band (12-35 Hz) of local field potentials recorded directly by subthalamic nucleus electrodes. Eight subjects were assessed in two 8-h stimulation sessions (first day, cDBS; second day, aDBS) with regular levodopa intake and during normal daily activities. The Unified Parkinson's Disease Rating Scale (UPDRS) part III scores, the Rush scale for dyskinesias, and the total electrical energy delivered to the tissues per second (TEEDs) were significantly lower in the aDBS session (relative UPDRS mean, cDBS: 0.46 ± 0.05, aDBS: 0.33 ± 0.04, p = 0.015; UPDRS part III rigidity subset mean, cDBS: 2.9143 ± 0.6551 and aDBS: 2.1429 ± 0.5010, p = 0.034; UPDRS part III standard deviation cDBS: 2.95, aDBS: 2.68; p = 0.047; Rush scale, cDBS 2.79 ± 0.39 versus aDBS 1.57 ± 0.23, p = 0.037; cDBS TEEDs mean: 28.75 ± 3.36 µj s
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.