Evidence map›Paper›PMID 34583993›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

An L1 retrotransposon insertion-induced deafness mouse model for studying the development and function of the cochlear stria vascularis.

Chenmeng Song, Jie Li, Shuang Liu, Hanqing Hou, Tong Zhu, Jiaofeng Chen, Lian Liu, Yichang Jia, Wei Xiong

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Frontiers in cell and developmental biology · 2025
    Article
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Chenmeng SongSchool of Life Sciences, Tsinghua University, Beijing, China 100084.
Jie LiSchool of Life Sciences, Tsinghua University, Beijing, China 100084.ORCID 0000-0003-4804-315X
Shuang LiuSchool of Life Sciences, Tsinghua University, Beijing, China 100084.ORCID 0000-0002-2439-9330
Hanqing HouSchool of Life Sciences, Tsinghua University, Beijing, China 100084.
Tong ZhuSchool of Life Sciences, Tsinghua University, Beijing, China 100084.ORCID 0000-0002-6339-1171
Jiaofeng ChenSchool of Life Sciences, Tsinghua University, Beijing, China 100084.
Lian LiuSchool of Life Sciences, Tsinghua University, Beijing, China 100084.ORCID 0000-0002-1833-9841
Yichang JiaIDG (International Data Group)/McGovern Institute for Brain Research at Tsinghua University, Beijing, China 100084.ORCID 0000-0002-7767-5714
Wei XiongSchool of Life Sciences, Tsinghua University, Beijing, China 100084; wei_xiong@tsinghua.edu.cn.ORCID 0000-0002-2784-7696
Chinese Institute for Brain Research · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dysregulation of ion and potential homeostasis in the scala media is the most prevalent cause of hearing loss in mammals. However, it is not well understood how the development and function of the stria vascularis regulates this fluid homeostasis in the scala media. From a mouse genetic screen, we characterize a mouse line, named

Indexed as

AnimalsChromosomes, MammalianDeafnessDisease Models, AnimalFemaleHair Cells, AuditoryHearingHearing LossHomeostasisMembrane PotentialsMiceMice, KnockoutPotassiumPregnancyRetroelementsStria VascularisPotassiumRetroelementsdeafnessendocochlear potentialLINE-1retrotransposonstria vascularis

Identifiers

PMID34583993
PMCPMC8501756
OpenAlexW3203425983

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.