Evidence map›Paper›PMID 34583944›Full record

ArticleJournal of neurology, neurosurgery, and psychiatry2021

Anxiety and depression symptoms after COVID-19 infection: results from the COVID Symptom Study app.

Kerstin Klaser, Ellen J Thompson, Long H Nguyen, Carole H Sudre, Michela Antonelli, Benjamin Murray, Liane S Canas, Erika Molteni, Mark S Graham, Eric Kerfoot and 15 more

Abstract read
In one paragraph

Article in Journal of neurology, neurosurgery, and psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  18. COVID-19 and New-Onset Psychosis: A Comprehensive Review.Journal of personalized medicine · 2023
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors.

Kerstin KlaserSchool of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.ORCID 0000-0002-5230-6939
Ellen J ThompsonDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Long H NguyenClinical & Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Harvard Medical School, Boston, Massachusetts, USA.
Carole H SudreSchool of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.
Michela AntonelliSchool of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.
Benjamin MurraySchool of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.
Liane S CanasSchool of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.
Erika MolteniSchool of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.
Mark S GrahamSchool of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.
Eric KerfootSchool of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.
Liyuan ChenSchool of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.
Jie DengSchool of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.
Anna MayZoe Limited, London, UK.
Christina HuZoe Limited, London, UK.
Andy GuestZoe Limited, London, UK.
Somesh SelvachandranZoe Limited, London, UK.
David A DrewClinical & Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Harvard Medical School, Boston, Massachusetts, USA.
Marc ModatSchool of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.
Andrew T ChanClinical & Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Harvard Medical School, Boston, Massachusetts, USA.
Jonathan WolfZoe Limited, London, UK.
Tim D SpectorDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Alexander HammersSchool of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.ORCID 0000-0001-9530-4848
Emma L DuncanDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Sebastien OurselinSchool of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.
Claire J StevesDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK claire.j.steves@kcl.ac.uk.ORCID 0000-0002-4910-0489

Funding

Dietary strategies for rational manipulation of the gut microbiome in inflammatory bowel diseaseK23DK125838 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI NGUYEN, LONG H · 2020 to 2024
$1.0M
Impact of Aspirin on the Gut Microbiome and Mucosal MicroenvironmentK01DK120742 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI DREW, DAVID A · 2020 to 2024
$793k
EPA EP-W-17-011Medical Research Council MC_PC_20030NIDDK NIH HHS K01 DK120742NIDDK NIH HHS K23 DK125838Wellcome Trust
6 · The paper itself

Abstract

backgroundMental health issues have been reported after SARS-CoV-2 infection. However, comparison to prevalence in uninfected individuals and contribution from common risk factors (eg, obesity and comorbidities) have not been examined. We identified how COVID-19 relates to mental health in the large community-based COVID Symptom Study.

methodsWe assessed anxiety and depression symptoms using two validated questionnaires in 413148 individuals between February and April 2021; 26998 had tested positive for SARS-CoV-2. We adjusted for physical and mental prepandemic comorbidities, body mass index (BMI), age and sex.

findingsOverall, 26.4% of participants met screening criteria for general anxiety and depression. Anxiety and depression were slightly more prevalent in previously SARS-CoV-2-positive (30.4%) vs SARS-CoV-2-negative (26.1%) individuals. This association was small compared with the effect of an unhealthy BMI and the presence of other comorbidities, and not evident in younger participants (≤40 years). Findings were robust to multiple sensitivity analyses. Association between SARS-CoV-2 infection and anxiety and depression was stronger in individuals with recent (<30 days) versus more distant (>120 days) infection, suggesting a short-term effect.

interpretationA small association was identified between SARS-CoV-2 infection and anxiety and depression symptoms. The proportion meeting criteria for self-reported anxiety and depression disorders is only slightly higher than prepandemic.

Indexed as

Mobile ApplicationsAdolescentAdultAgedAged, 80 and overAnxietyCOVID-19DepressionFemaleHumansMaleMental HealthMiddle AgedPrevalenceSARS-CoV-2Self ReportCOVID-19depressionpsychiatry

Identifiers

PMID34583944
PMCPMC8599635

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.