Evidence map›Paper›PMID 34583942›Full record

ArticleJournal of neurology, neurosurgery, and psychiatry2022

GBA variants influence cognitive status in amyotrophic lateral sclerosis.

Antonio Canosa, Maurizio Grassano, Cristina Moglia, Barbara Iazzolino, Laura Peotta, Salvatore Gallone, Maura Brunetti, Marco Barberis, Luca Sbaiz, Francesca Palumbo and 9 more

Open access · hybridAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, neurosurgery, and psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Brain metabolic connectivity in ALS due to C9ORF72 hexanucleotide expansion: a [European journal of nuclear medicine and molecular imaging · 2026
    Article
  2. Article
  3. Muscles (Basel, Switzerland) · 2024
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 2 countries.

Antonio Canosa *"Rita Levi Montalcini" Department of Neuroscience, ALS Centre, University of Turin, Turin, Italy.ORCID 0000-0001-5876-4079
Maurizio Grassano *"Rita Levi Montalcini" Department of Neuroscience, ALS Centre, University of Turin, Turin, Italy.
Cristina Moglia"Rita Levi Montalcini" Department of Neuroscience, ALS Centre, University of Turin, Turin, Italy.
Barbara Iazzolino"Rita Levi Montalcini" Department of Neuroscience, ALS Centre, University of Turin, Turin, Italy.
Laura Peotta"Rita Levi Montalcini" Department of Neuroscience, ALS Centre, University of Turin, Turin, Italy.
Salvatore GalloneSC Neurologia 1U, Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino, Turin, Italy.
Maura Brunetti"Rita Levi Montalcini" Department of Neuroscience, ALS Centre, University of Turin, Turin, Italy.
Marco BarberisLaboratory of Genetics, Department of Clinical Pathology, Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino, Turin, Italy.
Luca SbaizLaboratory of Genetics, Department of Clinical Pathology, Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino, Turin, Italy.
Francesca Palumbo"Rita Levi Montalcini" Department of Neuroscience, ALS Centre, University of Turin, Turin, Italy.
Sara Cabras"Rita Levi Montalcini" Department of Neuroscience, ALS Centre, University of Turin, Turin, Italy.
Umberto Manera"Rita Levi Montalcini" Department of Neuroscience, ALS Centre, University of Turin, Turin, Italy.
Rosario Vasta"Rita Levi Montalcini" Department of Neuroscience, ALS Centre, University of Turin, Turin, Italy.ORCID 0000-0002-0393-4736
Bryan TraynorNeuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, Porter Neuroscience Research Center, Bethesda, MD, USA.
Lucia CorradoDepartment of Health Sciences Interdisciplinary Research Center of Autoimmune Diseases, University of Eastern Piedmont Amedeo Avogadro School of Medicine, Novara, Piemonte, Italy.
Sandra D'AlfonsoDepartment of Health Sciences Interdisciplinary Research Center of Autoimmune Diseases, University of Eastern Piedmont Amedeo Avogadro School of Medicine, Novara, Piemonte, Italy.
Letizia MazziniALS Center, Department of Neurology, Azienda Ospedaliera Universitaria Maggiore della Carità, Novara, Italy.
Andrea Calvo *"Rita Levi Montalcini" Department of Neuroscience, ALS Centre, University of Turin, Turin, Italy.ORCID 0000-0002-5122-7243
Adriano Chio *"Rita Levi Montalcini" Department of Neuroscience, ALS Centre, University of Turin, Turin, Italy achio@usa.net.ORCID 0000-0001-9579-5341
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino · ITUniversity of Turin · ITUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro” · ITJohns Hopkins University · USNational Institute on Aging · US

Funding

Genetic characterization of atypical parkinsonismZIANS003154 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI SCHOLZ, SONJA · 2016 to 2025
$15.4M
Genome wide SNP analysis in Parkinson's diseaseZ01AG000949 · NIA · NATIONAL INSTITUTE ON AGING · PI SINGLETON, ANDREW B · 2006 to 2008
$2.6M
Intramural NIH HHS Z01 AG000949Intramural NIH HHS ZIA NS003154
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Amyotrophic Lateral SclerosisGlucosylceramidaseCognitionFrontotemporal DementiaHumansMutationGBA protein, humanGlucosylceramidaseALSfrontotemporal dementia

Identifiers

PMID34583942
PMCPMC8921570
OpenAlexW3204109042

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.