Evidence map›Paper›PMID 34583930›Full record

ArticleLife science alliance2021

The DREAM complex represses growth in response to DNA damage in

Lucas Lang, Aladár Pettkó-Szandtner, Hasibe Tunçay Elbaşı, Hirotomo Takatsuka, Yuji Nomoto, Ahmad Zaki, Stefan Dorokhov, Geert De Jaeger, Dominique Eeckhout, Masaki Ito and 4 more

Open access · goldAbstract read
In one paragraph

Article in Life science alliance, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 52 citations in OpenAlex.

  1. Cyclin' Through the Root: Developmental Control of Cell Cycle Progression in theAnnual review of cell and developmental biology · 2026
    Review
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  12. Emerging Role of the DREAM Complex in Cancer and Therapeutic Opportunities.International journal of molecular sciences · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 5 countries.

Lucas LangDepartment of Developmental Biology, University of Hamburg, Institute for Plant Sciences and Microbiology, Hamburg, Germany.
Aladár Pettkó-SzandtnerLaboratory of Proteomic Research, Biological Research Centre, Szeged, Hungary.
Hasibe Tunçay ElbaşıDepartment of Developmental Biology, University of Hamburg, Institute for Plant Sciences and Microbiology, Hamburg, Germany.ORCID 0000-0001-5492-5920
Hirotomo TakatsukaSchool of Biological Science and Technology, College of Science and Engineering, Kanazawa University, Kanazawa, Japan.
Yuji NomotoSchool of Biological Science and Technology, College of Science and Engineering, Kanazawa University, Kanazawa, Japan.
Ahmad ZakiDepartment of Biological Sciences, Centre for Systems and Synthetic Biology, Royal Holloway University of London, Egham, UK.
Stefan DorokhovDepartment of Biological Sciences, Centre for Systems and Synthetic Biology, Royal Holloway University of London, Egham, UK.
Geert De JaegerDepartment of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium.
Dominique EeckhoutDepartment of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium.
Masaki ItoSchool of Biological Science and Technology, College of Science and Engineering, Kanazawa University, Kanazawa, Japan.
Zoltán MagyarInstitute of Plant Biology, Biological Research Centre, Szeged, Hungary.
László BögreVlaams Instituut voor Biotechnologie (VIB) Center for Plant Systems Biology, Ghent, Belgium.
Maren HeeseDepartment of Developmental Biology, University of Hamburg, Institute for Plant Sciences and Microbiology, Hamburg, Germany maren.heese@uni-hamburg.de.ORCID 0000-0002-1070-9107
Arp SchnittgerDepartment of Developmental Biology, University of Hamburg, Institute for Plant Sciences and Microbiology, Hamburg, Germany arp.schnittger@uni-hamburg.de.ORCID 0000-0001-7067-0091
Universität Hamburg · DEKanazawa University · JPVlaams Instituut voor Biotechnologie · BEHUN-REN Szegedi Biológiai Kutatóközpont · HURoyal Holloway University of London · GB

Funding

Biotechnology and Biological Sciences Research Council BB/M025047/1
6 · The paper itself

Abstract

The DNA of all organisms is constantly damaged by physiological processes and environmental conditions. Upon persistent damage, plant growth and cell proliferation are reduced. Based on previous findings that RBR1, the only Arabidopsis homolog of the mammalian tumor suppressor gene retinoblastoma, plays a key role in the DNA damage response in plants, we unravel here the network of RBR1 interactors under DNA stress conditions. This led to the identification of homologs of every DREAM component in Arabidopsis, including previously not recognized homologs of LIN52. Interestingly, we also discovered NAC044, a mediator of DNA damage response in plants and close homolog of the major DNA damage regulator SOG1, to directly interact with RBR1 and the DREAM component LIN37B. Consistently, not only mutants in

Indexed as

ArabidopsisArabidopsis ProteinsCell Cycle CheckpointsDNA DamageDNA RepairE2F Transcription FactorsGene Expression Regulation, PlantMutant ProteinsMutationPlant RootsPlants, Genetically ModifiedSignal TransductionTrans-ActivatorsTranscription FactorsArabidopsis ProteinsE2Fb protein, ArabidopsisE2F Transcription FactorsMutant ProteinsRBR1 protein, ArabidopsisSOG1 protein, ArabidopsisTrans-ActivatorsTranscription Factors

Identifiers

PMID34583930
PMCPMC8500230
OpenAlexW3201754449

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.