ArticleAnimal microbiome2021
Low pathogenic avian influenza virus infection retards colon microbiota diversification in two different chicken lines.
Article in Animal microbiome, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- From Gut to Shot: Microbiome-Guided Strategies to Improve Vaccine Responses in Food Animals.Vaccines · 2026Review
- The 16S rRNA gene sequencing of gut microbiota in pigeons infected with pigeon paramyxovirus type 1.Frontiers in cellular and infection microbiology · 2026Article
- Effects of Increased Housing Space Without Altering Stocking Density on Body Weight, Stress, and Gut Microbiome in Broiler Chickens.Animals : an open access journal from MDPI · 2025Article
- Study of the 16S microbiome of swans died during the H5N1 outbreak in the Caspian seashore.Frontiers in veterinary science · 2025Article
- Influenza a virus subtype H9N2 infection induces respiratory microbiota dysbiosis in chickens via type-I interferon-mediated mechanisms.FEMS microbes · 2025Article
- Postbiotic-based recombinant receptor activator of NF-κB ligand enhanced oral vaccine efficiency in chicken.Applied microbiology and biotechnology · 2024Article
- Exploring the complexities of poultry respiratory microbiota: colonization, composition, and impact on health.Animal microbiome · 2024Review
- A live attenuatedFrontiers in veterinary science · 2024Article
- Alteration of the Chicken Upper Respiratory Microbiota, Following H9N2 Avian Influenza Virus Infection.Pathogens (Basel, Switzerland) · 2023Article
- Genetic Variations among Different Variants of G1-like Avian Influenza H9N2 Viruses and Their Pathogenicity in Chickens.Viruses · 2022Article
- Uncovering the core principles of the gut-lung axis to enhance innate immunity in the chicken.Frontiers in immunology · 2022Article
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Authors and funding
6 authors.
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Abstract
backgroundA commensal microbiota regulates and is in turn regulated by viruses during host infection which can influence virus infectivity. In this study, analysis of colon microbiota population changes following a low pathogenicity avian influenza virus (AIV) of the H9N2 subtype infection of two different chicken breeds was conducted.
methodsColon samples were taken from control and infected groups at various timepoints post infection. 16S rRNA sequencing on an Illumina MiSeq platform was performed on the samples and the data mapped to operational taxonomic units of bacterial using a QIIME based pipeline. Microbial community structure was then analysed in each sample by number of observed species and phylogenetic diversity of the population.
resultsWe found reduced microbiota alpha diversity in the acute period of AIV infection (day 2-3) in both Rhode Island Red and VALO chicken lines. From day 4 post infection a gradual increase in diversity of the colon microbiota was observed, but the diversity did not reach the same level as in uninfected chickens by day 10 post infection, suggesting that AIV infection retards the natural accumulation of colon microbiota diversity, which may further influence chicken health following recovery from infection. Beta diversity analysis indicated a bacterial species diversity difference between the chicken lines during and following acute influenza infection but at phylum and bacterial order level the colon microbiota dysbiosis was similar in the two different chicken breeds.
conclusionOur data suggest that H9N2 influenza A virus impacts the chicken colon microbiota in a predictable way that could be targeted via intervention to protect or mitigate disease.
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