ArticleBiomedical engineering online2021
Effect of guidewire insertion in fractional flow reserve procedure for real geometry using computational fluid dynamics.
Article in Biomedical engineering online, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Bio-Inspired Micro-Fin-Assisted Multi-Modal Vascular Intervention.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Influence of Rigid-Elastic Artery Wall of Carotid and Coronary Stenosis on Hemodynamics.Bioengineering (Basel, Switzerland) · 2022Article
- CT-Derived 3D Printing for Coronary Artery Cannulation Simulator Design Manufacturing.Bioengineering (Basel, Switzerland) · 2022Article
- Computational Pressure-Fluid Dynamics Applied to Index of Microcirculatory Resistance, Predicting the Prognosis of Drug-Coated Balloons Compared With Drug-Eluting Stents in STEMI Patients.Frontiers in physiology · 2022Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCoronary artery disease is an abnormal contraction of the heart supply blood vessel. It limits the oxygenated blood flow to the heart. Thus, diagnosing its severity helps physicians to select the appropriate treatment plan. Fractional flow reserve (FFR) is the most accurate method to pinpoint the stenosis severity. However, inserting the guidewire across stenosis may cause a false overestimation of severity.
methodsTo estimate the errors due to guidewire insertion, reconstructed three-dimensional coronary artery geometry from a patient-specific scan is used. A comprehensive three-dimensional blood flow model is developed. Blood is considered non-Newtonian and the flow is pulsatile. The model is numerically simulated using realistic boundary conditions.
resultsThe FFR value is calculated and compared with the actual flow ratio. Additionally, the ratio between pressure drop and distal dynamic pressure (CDP) is studied. The obtained results for each case are compared and analyzed with the case without a guidewire. It was found that placing the guidewire leads to overestimating the severity of moderate stenosis. It reduces the FFR value from 0.43 to 0.33 with a 23.26% error compared to 0.44 actual flow ratio and the CDP increases from 5.31 to 7.2 with a 35.6% error. FFR value in mild stenosis does not have a significant change due to placing the guidewire. The FFR value decreases from 0.83 to 0.82 compared to the 0.83 actual flow ratio.
conclusionConsequently, physicians should consider these errors while deciding the treatment plan.
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