ArticleJournal of the Royal Society, Interface2021
The energy of muscle contraction. IV. Greater mass of larger muscles decreases contraction efficiency.
Article in Journal of the Royal Society, Interface, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Inductive analysis of the spatial distribution characteristics of neurons that innervate skeletal muscle and their correlation with muscle phenotype.Neural regeneration research · 2026Article
- Effects of muscle mass on muscle force predictions in human movement.bioRxiv : the preprint server for biology · 2026Article
- Association between body roundness index and strength fitness in senior middle school students.Frontiers in public health · 2026Article
- Higher legs muscle mass reduces gross mechanical efficiency during moderate intensity cycling in young healthy men.Scientific reports · 2025Article
- Using physiologically based models to predict in vivo skeletal muscle energetics.The Journal of experimental biology · 2025Article
- Sprinters' and Marathon Runners' Performances Are Better Explained by Muscle Fibers' Percentage Cross-Sectional Area than Any Other Parameter of Muscle Fiber Composition.Sports (Basel, Switzerland) · 2025Article
- Optimizing Resistance Training for Sprint and Endurance Athletes: Balancing Positive and Negative Adaptations.Sports medicine (Auckland, N.Z.) · 2024Review
- Scaling of buccal mass growth and muscle activation determine the duration of feeding behaviours in the marine mollusc Aplysia californica.The Journal of experimental biology · 2024Article
- The energy of muscle contraction. IV. Greater mass of larger muscles decreases contraction efficiency.Journal of the Royal Society, Interface · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While skeletal muscle mass has been shown to decrease mass-specific mechanical work per cycle, it is not yet known how muscle mass alters contraction efficiency. In this study, we examined the effect of muscle mass on mass-specific metabolic cost and efficiency during cyclic contractions in simulated muscles of different sizes. We additionally explored how tendon and its stiffness alters the effects of muscle mass on mass-specific work, mass-specific metabolic cost and efficiency across different muscle sizes. To examine contraction efficiency, we estimated the metabolic cost of the cycles using established cost models. We found that for motor contractions in which the muscle was primarily active during shortening, greater muscle mass resulted in lower contraction efficiency, primarily due to lower mass-specific mechanical work per cycle. The addition of a tendon in series with the mass-enhanced muscle model improved the mass-specific work and efficiency per cycle with greater mass for motor contractions, particularly with a shorter excitation duty cycle, despite higher predicted metabolic cost. The results of this study indicate that muscle mass is an important determinant of whole muscle contraction efficiency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.