ArticleJournal of the Royal Society, Interface2021
A platform for high-fidelity patient-specific structural modelling of atherosclerotic arteries: from intravascular imaging to three-dimensional stress distributions.
Article in Journal of the Royal Society, Interface, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Automated Coronary Optical Coherence Tomography Feature Extraction with Application to Three-Dimensional Reconstruction.Tomography (Ann Arbor, Mich.) · 2022Pooled it
- Impact of lesion preparation-induced calcified plaque defects in vascular intervention for atherosclerotic disease: in silico assessment.Biomechanics and modeling in mechanobiology · 2025Article
- Morphology-Based Non-Rigid Registration of Coronary Computed Tomography and Intravascular Images Through Virtual Catheter Path Optimization.IEEE transactions on medical imaging · 2025Article
- Probing the limits and capabilities of diffusion models for the anatomic editing of digital twins.NPJ digital medicine · 2024Article
- Article
- Validation of biomechanical assessment of coronary plaque vulnerability based on intravascular optical coherence tomography and digital subtraction angiography.Quantitative imaging in medicine and surgery · 2024Article
- Fully automated construction of three-dimensional finite element simulations from Optical Coherence Tomography.Computers in biology and medicine · 2023Article
- Intravascular imaging of angioplasty balloon under-expansion during pre-dilation predicts hyperelastic behavior of coronary artery lesions.Frontiers in bioengineering and biotechnology · 2023Article
- The Need to Shift from Morphological to Structural Assessment for Carotid Plaque Vulnerability.Biomedicines · 2022Article
- Framework for lumen-based nonrigid tomographic coregistration of intravascular images.Journal of medical imaging (Bellingham, Wash.) · 2022Article
- Automated finite element approach to generate anatomical patient-specific biomechanical models of atherosclerotic arteries from virtual histology-intravascular ultrasound.Frontiers in medical technology · 2022Article
- Medical Image-Based Computational Fluid Dynamics and Fluid-Structure Interaction Analysis in Vascular Diseases.Frontiers in bioengineering and biotechnology · 2022Review
- An inverse method for mechanical characterization of heterogeneous diseased arteries using intravascular imaging.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
The pathophysiology of atherosclerotic lesions, including plaque rupture triggered by mechanical failure of the vessel wall, depends directly on the plaque morphology-modulated mechanical response. The complex interplay between lesion morphology and structural behaviour can be studied with high-fidelity computational modelling. However, construction of three-dimensional (3D) and heterogeneous models is challenging, with most previous work focusing on two-dimensional geometries or on single-material lesion compositions. Addressing these limitations, we here present a semi-automatic computational platform, leveraging clinical optical coherence tomography images to effectively reconstruct a 3D patient-specific multi-material model of atherosclerotic plaques, for which the mechanical response is obtained by structural finite-element simulations. To demonstrate the importance of including multi-material plaque components when recovering the mechanical response, a computational case study was conducted in which systematic variation of the intraplaque lipid and calcium was performed. The study demonstrated that the inclusion of various tissue components greatly affected the lesion mechanical response, illustrating the importance of multi-material formulations. This platform accordingly provides a viable foundation for studying how plaque micro-morphology affects plaque mechanical response, allowing for patient-specific assessments and extension into clinically relevant patient cohorts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.