Evidence map›Paper›PMID 34583344›Full record

Trial reportThe American journal of tropical medicine and hygiene2021

Azithromycin versus Amoxicillin and Malarial Parasitemia among Children with Uncomplicated Severe Acute Malnutrition: A Randomized Controlled Trial.

Ali Sié, Clarisse Dah, Millogo Ourohiré, Moussa Ouédraogo, Valentin Boudo, Ahmed M Arzika, Elodie Lebas, Fanice Nyatigo, Benjamin F Arnold, Kieran S O'Brien and 1 more

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of tropical medicine and hygiene, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Ali SiéCentre de Recherche en Santé de Nouna, Burkina Faso.
Clarisse DahCentre de Recherche en Santé de Nouna, Burkina Faso.
Millogo OurohiréCentre de Recherche en Santé de Nouna, Burkina Faso.
Moussa OuédraogoCentre de Recherche en Santé de Nouna, Burkina Faso.
Valentin BoudoCentre de Recherche en Santé de Nouna, Burkina Faso.
Ahmed M ArzikaCentre de Recherche et Interventions en Santé Publique, Niamey, Niger.
Elodie LebasFrancis I Proctor Foundation, University of California, San Francisco, California.
Fanice NyatigoFrancis I Proctor Foundation, University of California, San Francisco, California.
Benjamin F ArnoldFrancis I Proctor Foundation, University of California, San Francisco, California.
Kieran S O'BrienFrancis I Proctor Foundation, University of California, San Francisco, California.
Catherine E OldenburgFrancis I Proctor Foundation, University of California, San Francisco, California.
Centre de Recherche en Santé de Nouna · BFSan Francisco Foundation · USUniversity of California, San Francisco · US

Funding

Azithromycin in the Outpatient Management of Severe Acute MalnutritionR21HD100932 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI OLDENBURG, CATHERINE ELIZABETH · 2020 to 2021
$395k
NICHD NIH HHS R21 HD100932
6 · The paper itself

Abstract

Antibiotics are recommended by the WHO as part of the management of uncomplicated severe acute malnutrition in children. We evaluated whether azithromycin, an antibiotic with antimalarial properties, improved malarial parasitemia outcomes in children with severe acute malnutrition compared with amoxicillin, an antibiotic commonly used for severe acute malnutrition that does not have antimalarial properties. Total of 301 children were randomized (1:1) to a single oral dose of azithromycin or a 7-day course of amoxicillin and followed for 8 weeks. We found no significant evidence that children receiving azithromycin had improved parasitemia outcomes relative to amoxicillin. Although azithromycin may have advantages over amoxicillin in terms of dosing and administration for uncomplicated severe acute malnutrition, it may not yield additional benefit for malaria outcomes.

Indexed as

AmoxicillinAnti-Infective AgentsAzithromycinBurkina FasoChild Nutrition DisordersChild, PreschoolHumansInfantInfant Nutrition DisordersMalariaParasitemiaTreatment OutcomeAmoxicillinAnti-Infective AgentsAzithromycin

Identifiers

PMID34583344
PMCPMC8733515
OpenAlexW3202064950

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.