ArticleThe American journal of tropical medicine and hygiene2021
Nonrandom Selection and Multiple Blood Feeding of Human Hosts by Anopheles Vectors: Implications for Malaria Transmission in Papua New Guinea.
Article in The American journal of tropical medicine and hygiene, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 33 citations in OpenAlex.
- Associations of maternal iron deficiency with malaria infection in a cohort of pregnant Papua New Guinean women.Malaria journal · 2022Trial
- Impact of mass distribution on insecticide-treated net coverage and usage in three high burden malaria provinces of Papua New Guinea.Infectious diseases of poverty · 2026Article
- Insecticidal efficacy of residual spraying with deltamethrin-clothianidin (FludoraParasites & vectors · 2026Article
- Characterization of entomological drivers of malaria transmission in five villages, Keerom Regency, Papua, Indonesia.PloS one · 2026Article
- An All-in-One Metabarcoding Approach to Mosquito and Arbovirus Xenosurveillance.Molecular ecology resources · 2025Article
- Scalable and cost-effective methods for xenomonitoring of P. falciparum and antimalarial drug resistance validated with laboratory and wild-caught mosquitoes.Scientific reports · 2025Article
- Effects of recombination on multi-drug resistance evolution in Plasmodium falciparum malaria.PLoS computational biology · 2025Article
- Anopheles mosquito exposure is associated with age, gender and bed net use in areas in Uganda experiencing varying malaria transmission intensity.The Journal of infection · 2025Article
- The spatial heterogeneity of malaria transmission: An entomological investigation in a highly endemic setting of Burkina Faso.Current research in parasitology & vector-borne diseases · 2025Article
- À la carte: how mosquitoes choose their blood meals.Trends in parasitology · 2024Review
- Plasmodium falciparum infection in humans and mosquitoes influence natural Anopheline biting behavior and transmission.Nature communications · 2024Article
- bistro: An R package for vector bloodmeal identification by short tandem repeat overlap.Methods in ecology and evolution · 2024Article
- Symptomatic and asymptomatic malaria prevalence and its determinant factors in pastoral communities of Waghemira Zone, Northeast Ethiopia: A community-based cross-sectional study.Health science reports · 2023Article
- Genotyping of Anopheles mosquito blood meals reveals nonrandom human host selection: implications for human-to-mosquito Plasmodium falciparum transmission.Malaria journal · 2023Article
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Authors and funding
10 authors at 3 institutions in 4 countries.
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Abstract
Nonrandom selection and multiple blood feeding of human hosts by Anopheles mosquitoes may exacerbate malaria transmission. Both patterns of blood feeding and their relationship to malaria epidemiology were investigated in Anopheles vectors in Papua New Guinea (PNG). Blood samples from humans and mosquito blood meals were collected in villages and human genetic profiles ("fingerprints") were analyzed by genotyping 23 microsatellites and a sex-specific marker. Frequency of blood meals acquired from different humans, identified by unique genetic profiles, was fitted to Poisson and negative binomial distributions to test for nonrandom patterns of host selection. Blood meals with more than one genetic profiles were classified as mosquitoes that fed on multiple humans. The age of a person bitten by a mosquito was determined by matching the blood-meal genetic profile to the villagers' genetic profiles. Malaria infection in humans was determined by PCR test of blood samples. The results show nonrandom distribution of blood feeding among humans, with biased selection toward males and individuals aged 15-30 years. Prevalence of Plasmodium falciparum infection was higher in this age group, suggesting males in this age range could be super-spreaders of malaria parasites. The proportion of mosquitoes that fed on multiple humans ranged from 6% to 13% among villages. The patterns of host utilization observed here can amplify transmission and contribute to the persistence of malaria in PNG despite efforts to suppress it with insecticidal bed nets. Excessive feeding on males aged 15-30 years underscores the importance of targeted interventions focusing on this demographic group.
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