Evidence map›Paper›PMID 34583117›Full record

ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2021

Small vessel disease disrupts EEG postural brain networks in 'unexplained dizziness in the elderly'.

R T Ibitoye, P Castro, A Desowska, J Cooke, A E Edwards, O Guven, Q Arshad, L Murdin, D Kaski, A M Bronstein

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Chronic dizziness in older adults: Disrupted sensorimotor EEG beta oscillations during postural instability.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025
    Article
  5. Article
  6. Article
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  8. Article
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  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

R T IbitoyeNeuro-otology Unit, Imperial College London, London, UK; The Computational, Cognitive and Clinical Neuroimaging Laboratory (C3NL), Imperial College London, London, UK.
P CastroNeuro-otology Unit, Imperial College London, London, UK.
A DesowskaThe Computational, Cognitive and Clinical Neuroimaging Laboratory (C3NL), Imperial College London, London, UK.
J CookeNeuro-otology Unit, Imperial College London, London, UK.
A E EdwardsNeuro-otology Unit, Imperial College London, London, UK.
O GuvenNeuro-otology Unit, Imperial College London, London, UK.
Q ArshadNeuro-otology Unit, Imperial College London, London, UK; inAmind Laboratory, Department of Neuroscience, Psychology and Behaviour, University of Leicester, Leicester, UK.
L MurdinGuy's and St Thomas' NHS Foundation Trust, London, UK.
D KaskiNeuro-otology Unit, Imperial College London, London, UK; Department of Clinical and Movement Neurosciences, University College London, London, UK.
A M BronsteinNeuro-otology Unit, Imperial College London, London, UK. Electronic address: a.bronstein@imperial.ac.uk.
Imperial College London · GBWellcome Centre for Human Neuroimaging · GBGuy's and St Thomas' NHS Foundation Trust · GBUniversity College London · GBUniversity of Leicester · GB

Funding

The Dunhill Medical Trust R481/0516
6 · The paper itself

Abstract

objectiveTo examine the hypothesis that small vessel disease disrupts postural networks in older adults with unexplained dizziness in the elderly (UDE).

methodsSimultaneous electroencephalography and postural sway measurements were undertaken in upright, eyes closed standing, and sitting postures (as baseline) in 19 younger adults, 33 older controls and 36 older patients with UDE. Older adults underwent magnetic resonance imaging to determine whole brain white matter hyperintensity volumes, a measure of small vessel disease. Linear regression was used to estimate the effect of instability on electroencephalographic power and connectivity.

resultsAgeing increased theta and alpha desynchronisation on standing. In older controls, delta and gamma power increased, and theta and alpha power reduced with instability. Dizzy older patients had higher white matter hyperintensity volumes and more theta desynchronisation during periods of instability. White matter hyperintensity volume and delta power during periods of instability were correlated, positively in controls but negatively in dizzy older patients. Delta power correlated with subjective dizziness and instability.

conclusionsNeural resource demands of postural control increase with age, particularly in patients with UDE, driven by small vessel disease. SIGNIFICANCE: EEG correlates of postural control saturate in older adults with UDE, offering a neuro-physiological basis to this common syndrome.

Indexed as

AdultAgedAged, 80 and overAgingBrainBrain WavesCerebral Small Vessel DiseasesDizzinessElectroencephalographyFemaleHumansMaleMiddle AgedNerve NetPostural BalanceStanding PositionDizzinessEEGElderlyPostural controlSmall vessel diseaseUnexplained dizziness in the elderly

Identifiers

PMID34583117
PMCPMC8559782
OpenAlexW3196367331

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.