ArticleNeurotoxicology2021
Prenatal exposure to a mixture of organophosphate esters and intelligence among 8-year-old children of the HOME Study.
Article in Neurotoxicology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Prenatal exposure to organophosphate esters and child cognitive development in the MARBLES prospective cohort.International journal of hygiene and environmental health · 2026Article
- Association between gestational and childhood exposures to organophosphate esters and social skill, problem behavior among adolescents.Environmental research · 2026Article
- Identifying associations and key early life exposure windows for organophosphate esters and adolescent brain morphometry in the HOME study.Environmental research · 2026Article
- Prenatal exposure to organophosphate ester flame retardants and child cognition: Findings from the environmental influences on child Health Outcomes cohort.Environmental pollution (Barking, Essex : 1987) · 2026Article
- Cumulative childhood lead exposure estimation and school-age IQ in a prospective birth cohort.Environmental health : a global access science source · 2025Article
- Prenatal Persistent Exposure to Organophosphate Esters and Early Childhood Brain Development: A Longitudinal Analysis.Environment & health (Washington, D.C.) · 2025Article
- Prenatal exposure to organophosphate ester flame retardants and behavioral outcomes in early childhood in the Environmental influences on Child Health Outcomes (ECHO) cohort.Environment international · 2025Article
- Mechanisms of Flame Retardant Toxicity and Their Impacts on Anxiety and Cognition in the Brain.Endocrinology · 2025Review
- Association between exposure to organophosphate esters and cognitive function in older adults in the United States: NHANES 2011-2014.BMC geriatrics · 2025Article
- Gestational exposure to environmental chemical mixtures and cognitive abilities in children: A pooled analysis of two North American birth cohorts.Environment international · 2025Article
- Gestational exposure to organophosphate esters and autism spectrum disorder and other non-typical development in a cohort with elevated familial likelihood.Environmental research · 2024Article
- Gestational organophosphate esters (OPEs) and executive function in adolescence: The HOME Study.Environmental research · 2024Article
- Exposure to organophosphate esters and maternal-child health.Environmental research · 2024Review
- Prenatal exposures to organophosphate ester metabolites and early motor development in the MADRES cohort.Environmental pollution (Barking, Essex : 1987) · 2024Article
- Article
- Machine learning reveals common transcriptomic signatures across rat brain and placenta following developmental organophosphate ester exposure.Toxicological sciences : an official journal of the Society of Toxicology · 2023Article
- Prenatal organophosphate ester exposure and executive function in Norwegian preschoolers.Environmental epidemiology (Philadelphia, Pa.) · 2023Article
- Maternal organophosphate flame retardant exposure alters the developing mesencephalic dopamine system in fetal rat.Toxicological sciences : an official journal of the Society of Toxicology · 2023Article
- Childhood urinary organophosphate esters and cognitive abilities in a longitudinal cohort study.Environmental research · 2022Article
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Authors and funding
12 authors at 7 institutions in 2 countries.
Funding
Abstract
Many environmental chemicals are being identified as suspected neurotoxicants based on the findings of both experimental and epidemiological studies. Organophosphate esters (OPEs), which are among the chemicals that have replaced neurotoxic polybrominated diphenyl ethers (PBDEs) after 2004, have also become an important public health topic as evidence regarding their potential for early-life neurotoxicity is growing. In 233 mother child pairs from Cincinnati, OH, we measured concentrations of the OPE metabolites bis(1,3-dichloro-2-propyl) phosphate (BDCIPP), bis-2-chloroethyl phosphate (BCEP), diphenyl phosphate (DPHP), and di-n-butyl phosphate (DNBP) in the urine of pregnant women at 16 and 26 weeks gestation and at delivery. At age 8 years, we assessed children's cognition using the Wechsler Intelligence Scale for Children-IV. In models adjusted for maternal race, income, body mass index, and IQ, maternal urinary BCEP was associated with a modest increase in child full-scale IQ (ß: 0.81 per a ln-unit BCEP increase; 95 % CI: 0.00, 1.61) while other OPEs were not associated with changes in full-scale IQ or any IQ subscales. Maternal serum PBDE concentrations did not confound the relationships between urinary OPE metabolites and child IQ. Using Bayesian kernel machine regression, we did not find that concentrations of a mixture of OPE metabolites during gestation was associated with any child cognition measures. The results of this study are not consistent with other published work, and a larger sample size would be beneficial to explore potential associations more fully. Therefore, additional studies are necessary to continue studying prenatal OPE exposure and child neurodevelopment and behavior.
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