Evidence map›Paper›PMID 34582824›Full record

ReviewJournal of molecular and cellular cardiology2022

Reverse cardio-oncology: Exploring the effects of cardiovascular disease on cancer pathogenesis.

Graeme J Koelwyn, Joseph Pierre Aboumsallem, Kathryn J Moore, Rudolf A de Boer

Open access · hybridAbstract readReview
In one paragraph

Review in Journal of molecular and cellular cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 69 citations in OpenAlex.

  1. Article
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  3. Review
  4. Article
  5. Hypertension-cancer recurrence crosstalk: implications for survivorship care.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Article
  6. Review
  7. Bidirectional Association between Atrial Fibrillation and Ovarian Cancer: Evidence from the UK Biobank and Mendelian Randomization.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026
    Article
  8. Article
  9. Review
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  11. Article
  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Graeme J KoelwynFaculty of Health Sciences, Simon Fraser University, Burnaby, Canada; Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, Canada.
Joseph Pierre AboumsallemUniversity Medical Center Groningen, University of Groningen, Department of Cardiology, Groningen, the Netherlands.
Kathryn J MooreNYU Cardiovascular Research Center, The Leon H. Charney Division of Cardiology, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA. Electronic address: kathryn.moore@nyumc.org.
Rudolf A de BoerUniversity Medical Center Groningen, University of Groningen, Department of Cardiology, Groningen, the Netherlands. Electronic address: r.a.de.boer@umcg.nl.
University of Groningen · NLNew York University · USSt. Paul's Hospital · CA

Funding

Resolving Macrophage Inflammation in Atherosclerotic Plaques and Other Sites in Insulin ResistanceP01HL131481 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ANN MARIE SCHMIDT · 2017 to 2026
$27.3M
Non-coding RNA regulation of cholesterol homeostasis and atherosclerosisR35HL135799 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MOORE, KATHRYN J · 2017 to 2023
$6.7M
NHLBI NIH HHS P01 HL131481NHLBI NIH HHS R35 HL135799
6 · The paper itself

Abstract

The field of cardio-oncology has emerged in response to the increased risk of cardiovascular disease (CVD) in patients with cancer. However, recent studies suggest a more complicated CVD-cancer relationship, wherein development of CVD, either prior to or following a cancer diagnosis, can also lead to increased risk of cancer and worse outcomes for patients. In this review, we describe the current evidence base, across epidemiological as well as preclinical studies, which supports the emerging concept of 'reverse-cardio oncology', or CVD-induced acceleration of cancer pathogenesis.

Indexed as

Cardiovascular DiseasesNeoplasmsHumansMedical OncologyCancer progressionCancer riskCardio-oncologyCardiovascular disease

Identifiers

PMID34582824
PMCPMC8816816
OpenAlexW3204073309

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.