ReviewCurrent biology : CB2021
Dynamic changes in epithelial cell packing during tissue morphogenesis.
Review in Current biology : CB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed.
- Mitotic shape changes drive spatiotemporally segregated cell-contact rearrangements in a proliferating epithelium.Current biology : CB · 2026Article
- Whole tissue imaging of cellular boundaries at sub-micron resolutions for deep learning cell segmentation: Applications in the analysis of epithelial bending of ectoderm.Developmental dynamics : an official publication of the American Association of Anatomists · 2026Article
- Steady-state epithelial apical flatness is characterized by MLCK morphodynamics and asynchronous CaMolecular biology of the cell · 2026Article
- Modeling epithelial deformation and cell rearrangement in response to external forces during Zebrafish epiboly.NPJ systems biology and applications · 2026Article
- Cell rearrangement progression along the apical-basal axis is linked with 3D epithelial tissue structure.PRX life · 2026Article
- Biomechanics-Driven 3D Architecture Inference from Histology Using CellSqueeze3D.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Cilia-driven epithelial folding and unfolding in an early diverging animal.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Spatially organized cellular communities shape functional tissue architecture in the pancreas.Science advances · 2025Article
- High-Resolution Heterogeneous Hydrogel Printing Using a Home Projector.Small methods · 2025Article
- The Compartmental and Fibrillar Polyhedral Architecture of Fascia: An Assessment of Connective Tissue Anatomy Without Its Abstract Classifications.Life (Basel, Switzerland) · 2025Article
- Cell Contractile Forces Drive Spatiotemporal Morphogenesis in 4D Bioprinted Living Constructs.Matter · 2025Article
- Spatiotemporal distribution of the glycoprotein pherophorin II reveals stochastic geometry of the growing ECM ofProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Capturing nematic order on tissue surfaces of arbitrary geometry.Nature communications · 2025Article
- Basal Cell-Contact Dynamics Influence Tissue Packing in a Proliferating Mammalian Epithelium.bioRxiv : the preprint server for biology · 2025Article
- Shaping epithelial tissues by stem cell mechanics in development and cancer.Nature reviews. Molecular cell biology · 2025Review
- Mucosal Immunity: Lessons from the Lower Respiratory and Small Intestinal Epithelia.Biomedicines · 2025Review
- An eGFP-Col4a2 mouse model reveals basement membrane dynamics underlying hair follicle morphogenesis.The Journal of cell biology · 2025Article
- Inferring active and passive mechanical drivers of epithelial convergent extension.bioRxiv : the preprint server for biology · 2025Article
- Tending to the Facial Surfaces of a Mathematical Biology Head-Scratcher: Why Does the Head of the Sea TurtleAnimals : an open access journal from MDPI · 2025Article
- Lineage Tracing by Light-Sheet Microscopy and Computational Reconstruction.Methods in molecular biology (Clifton, N.J.) · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Cell packing - the spatial arrangement of cells - determines the shapes of organs. Recently, investigations of organ development in a variety of model organisms have uncovered cellular mechanisms that are used by epithelial tissues to change cell packing, and thereby their shapes, to generate functional architectures. Here, we review these cellular mechanisms across a wide variety of developmental processes in vertebrates and invertebrates and identify a set of common motifs in the morphogenesis toolbox that, in combination, appear to allow any change in tissue shape. We focus on tissue elongation, folding and invagination, and branching. We also highlight how these morphogenetic processes are achieved by cell-shape changes, cell rearrangements, and oriented cell division. Finally, we describe approaches that have the potential to engineer three-dimensional tissues for both basic science and translational purposes. This review provides a framework for future analyses of how tissues are shaped by the dynamics of epithelial cell packing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.