ReviewNeuron2021
Cellular activity in insular cortex across seconds to hours: Sensations and predictions of bodily states.
Review in Neuron, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed, 95 citations in OpenAlex.
- Neural mechanisms of mindfulness-based stress reduction in asthma.Scientific reports · 2026Trial
- Article
- Signaling of salience and prediction errors by anterior insula neurons.Biochemical and biophysical research communications · 2026Article
- Insular Somatostatin Interneurons Are Targeted by Motor Cortex Efferents and Modulate Affective States.Biological psychiatry global open science · 2026Article
- Article
- Article
- A brain stem circuit integrating reflexive and anticipatory salivation.Cell reports · 2026Article
- Parietal cortex is causally required for state-dependent decisions.Cell reports · 2025Article
- Review
- Insular cortex predictions regulate glucose homeostasis.bioRxiv : the preprint server for biology · 2025Article
- Linear and categorical coding units in the mouse gustatory cortex drive population dynamics and behavior in taste decision-making.bioRxiv : the preprint server for biology · 2025Article
- Parietal cortex is causally required for state-dependent decisions.bioRxiv : the preprint server for biology · 2025Article
- A spatial single-cell atlas of the claustro-insular region uncovers key regulators of neuronal identity and excitability.Nature communications · 2025Article
- The mouse posterior insular cortex encodes expressive and receptive aspects of courtship vocalizations.Cell reports · 2025Article
- Social Exclusion Amplifies Behavioral Responses to Physical Pain via Insular Neuromodulation.Research square · 2025Article
- Interplay Between Cortical and Neurocardiac Interoceptive Processes and its Association with Self-Reported Interoceptive Sensibility.Brain topography · 2025Article
- Direct interoceptive input to the insular cortex shapes learned feeding behavior.bioRxiv : the preprint server for biology · 2025Article
- Social Exclusion Amplifies Behavioral Responses to Physical Pain via Insular Neuromodulation.bioRxiv : the preprint server for biology · 2025Article
- A top-down insular cortex circuit crucial for non-nociceptive fear learning.Science advances · 2025Article
- Melanin-concentrating hormone and orexin shape social affective behavior via action in the insular cortex of rat.Psychopharmacology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Our wellness relies on continuous interactions between our brain and body: different organs relay their current state to the brain and are regulated, in turn, by descending visceromotor commands from our brain and by actions such as eating, drinking, thermotaxis, and predator escape. Human neuroimaging and theoretical studies suggest a key role for predictive processing by insular cortex in guiding these efforts to maintain bodily homeostasis. Here, we review recent studies recording and manipulating cellular activity in rodent insular cortex at timescales from seconds to hours. We argue that consideration of these findings in the context of predictive processing of future bodily states may reconcile several apparent discrepancies and offer a unifying, heuristic model for guiding future work.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.