Evidence map›Paper›PMID 34582771›Full record

ArticleDevelopmental cell2021

Is developmental synchrony enabled by CTCF residence time?

Hsiao-Lin V Wang, Victor G Corces

Open access · greenAbstract readComment
In one paragraph

Article in Developmental cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Hsiao-Lin V WangDepartment of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA.
Victor G CorcesDepartment of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address: vcorces@emory.edu.
Emory University · US

Funding

Nuclear Organization and FunctionR35GM139408 · NIGMS · EMORY UNIVERSITY · PI CORCES, VICTOR G. · 2021 to 2025
$2.5M
Mechanisms of bisphenol A induced epigenomic alterations in the mammalian germlineF32ES031827 · NIEHS · EMORY UNIVERSITY · PI WANG, HSIAO-LIN V. · 2020 to 2022
$225k
NIEHS NIH HHS F32 ES031827NIGMS NIH HHS R35 GM139408
6 · The paper itself

Abstract

Depletion of CTCF in cultured cells has minor effects on transcription whereas its mutation leads to embryonic lethality and developmental defects. In a recent issue of Nature Cell Biology, Soochit et al. (2021) show that the residence time of CTCF on DNA may explain its critical role in cell differentiation.

Indexed as

Repressor ProteinsCCCTC-Binding FactorCell DifferentiationCell LineCCCTC-Binding FactorRepressor Proteins

Identifiers

PMID34582771
PMCPMC8883576
OpenAlexW3204508679

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.