Trial reportThe American journal of drug and alcohol abuse2021
Alcohol-related changes in behaviors and characteristics from the baseline to the randomization session for treatment and non-treatment seeking participants with alcohol use disorder.
Trial report in The American journal of drug and alcohol abuse, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
1 citing paper in PubMed, 1 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
6 authors at 4 institutions in 1 country.
Kimberly GoodyearCenter for Alcohol and Addiction Studies, Department of Behavioral and Social Sciences, Brown University, Providence, RI, USA.ORCID 0000-0001-6937-8974
Talia R Vasaturo-KolodnerCenter for Alcohol and Addiction Studies, Department of Behavioral and Social Sciences, Brown University, Providence, RI, USA.
George A KennaCenter for Alcohol and Addiction Studies, Department of Psychiatry and Human Behavior, Brown University, Providence, RI, USA.
Robert M SwiftCenter for Alcohol and Addiction Studies, Department of Psychiatry and Human Behavior, Brown University, Providence, RI, USA.
Lorenzo LeggioCenter for Alcohol and Addiction Studies, Department of Behavioral and Social Sciences, Brown University, Providence, RI, USA.ORCID 0000-0001-7284-8754
Carolina L Haass-KofflerCenter for Alcohol and Addiction Studies, Department of Behavioral and Social Sciences, Brown University, Providence, RI, USA.ORCID 0000-0002-5634-5679
Brown University · USNational Institute on Drug Abuse · USNational Institutes of Health · USProvidence College · US
Funding
Clinical Psychoneuroendocrinology and Neuropsychopharmacology (CPN)ZIAAA000218 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI LEGGIO, LORENZO · 2013 to 2020
$22.8M
Using wearables and EMA to examine the links between cannabis and depressionP20GM130414 · NIGMS · BROWN UNIVERSITY · PI PETER M. MONTI · 2019 to 2026
$22.0M
Clinical Psychoneuroendocrinology and Neuropsychopharmacology (CPN)ZIADA000635 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI LEGGIO, LORENZO · 2020 to 2025
$15.2M
A focus on alpha-1 blockade as a novel pharmacological treatment for alcohol use disorderR01AA027760 · NIAAA · BROWN UNIVERSITY · PI HAASS-KOFFLER, CAROLINA LUISA · 2019 to 2023
$2.6M
Aripiprazole and Topiramate on Free-Choice Alcohol UseR01AA015753 · NIAAA · BROWN UNIVERSITY · PI SWIFT, ROBERT M · 2007 to 2011
$2.5M
Lead optimization of novel CRFBP-CRFR2 complex modulators for alcohol use disorderR01AA026589 · NIAAA · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI SHEFFLER, DOUGLAS J · 2019 to 2021
$2.4M
Matching 5-HT Genotypes to Serotonergic Medications for AlcoholismR01AA016079 · NIAAA · BROWN UNIVERSITY · PI KENNA, GEORGE A. · 2007 to 2010
$1.5M
Mifepristone As A Pharmacological Intervention For Stress-Induced Alcohol DrinkingK01AA023867 · NIAAA · BROWN UNIVERSITY · PI HAASS-KOFFLER, CAROLINA LUISA · 2016 to 2020
$901k
The Neural Mechanisms Associated With Alcohol and Cigarette Craving in Alcohol Use Disorder Smokers During Oxytocin TreatmentK01AA026874 · NIAAA · BROWN UNIVERSITY · PI GOODYEAR, KIMBERLY · 2019 to 2023
$842k
Effects of Ghrelin on Alcohol Cue Reactivity and CravingR21AA019709 · NIAAA · BROWN UNIVERSITY · PI KENNA, GEORGE A. · 2010 to 2011
$436k
A Novel Pharmacotherapy for Alcoholism and Alcohol Liver DiseaseR21AA021128 · NIAAA · BROWN UNIVERSITY · PI KENNA, GEORGE A. · 2012 to 2013
$431k
Probenecid as pharmacotherapy for alcohol use disorderR21AA027614 · NIAAA · BROWN UNIVERSITY · PI HAASS-KOFFLER, CAROLINA LUISA · 2020 to 2021
backgroundParticipants who are enrolled in randomized controlled trials (RCTs) may be more motivated to change their behaviors after being enrolled in a study and that motivation may vary by treatment status.
objectivesThe objectives of this secondary analysis were to investigate if changes in alcohol-related behaviors/characteristics from the baseline to the randomization session differed overall and to assess those differences between non-treatment and treatment seeking individuals with alcohol use disorder (AUD).
methodsOur sample included participants from eight RCTs conducted at Brown University (
resultsResults showed that there were baseline differences, such as increased AUD severity and craving for alcohol in treatment seeking participants (
conclusionsThese findings demonstrated that alcohol-related behaviors and characteristics changed after enrollment. Severity, craving and drinking behaviors also differed between treatment-seeking status, which can potentially impact medication development stages for AUD such as clinical trial eligibility, enrollment and study outcomes.
Indexed as
AlcoholismAlcohol DrinkingCravingFemaleHumansMaleRandom Allocationalcohol use disorderbaselinemotivationnon-treatment seekersrandomizationsessionTreatment seekers
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Alcohol-related changes in behaviors and characteristics from the baseline to the randomization session for treatment and non-treatment seeking participants with alcohol use disorder. · full record | OpenQuestion