ArticleESC heart failure2021
Prognostic value of left atrial strain in patients with wild-type transthyretin amyloid cardiomyopathy.
Article in ESC heart failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Prognostic value of left atrial function in cardiac amyloidosis: a systematic review and meta‑analysis.The international journal of cardiovascular imaging · 2026Pooled it
- Musculoskeletal manifestations associated with transthyretin-mediated (ATTR) amyloidosis: a systematic review.BMC musculoskeletal disorders · 2023Pooled it
- Applications of Left Atrial Strain in Cardiovascular Disease: A Comprehensive Review of Recent Evidence.Reviews in cardiovascular medicine · 2026Review
- Combined assessment of left ventricular and atrial function for transthyretin amyloid cardiomyopathy.Heart and vessels · 2026Article
- Right Atrial Function as a Novel Predictor for New-Onset Atrial Fibrillation in Transthyretin Amyloid Cardiomyopathy.Journal of the American Heart Association · 2026Article
- Clinical Relevance of Left Atrial Early Diastolic Strain Rate as a Predictor of Left Atrial Remodeling Following Mitral Valve Repair.Circulation reports · 2025Article
- Echocardiographic risk stratification in light chain and transthyretin amyloidosis: a meta-analysis.European heart journal open · 2025Article
- Left Atrial Strain-Current Review of Clinical Applications.Diagnostics (Basel, Switzerland) · 2025Review
- Atrial cardiomyopathy in cardiac amyloidosis: clinical imaging and manifestations.NPJ cardiovascular health · 2025Article
- Prognostic value of left atrial stiffness in patients undergoing transcatheter aortic valve implantation.International journal of cardiology. Heart & vasculature · 2025Article
- Clinical significance of the estimation of pulmonary-right ventricular uncoupling in patients with transthyretin amyloid cardiomyopathy.European heart journal. Imaging methods and practice · 2025Article
- Effect of tafamidis on left atrial function of patients with transthyretin amyloid cardiomyopathy.Heart and vessels · 2024Article
- A new staging system using right atrial strain in patients with immunoglobulin light-chain cardiac amyloidosis.ESC heart failure · 2024Article
- Incremental diagnostic and prognostic utility of left atrial deformation in heart failure using speckle tracking echocardiography.Heart failure reviews · 2024Review
- The Clinical Applications of Left Atrial Strain: A Comprehensive Review.Medicina (Kaunas, Lithuania) · 2024Review
- Left ventricular and atrial myocardial strain in heart failure with preserved ejection fraction: the evidence so far and prospects for phenotyping strategy.Cardiovascular ultrasound · 2024Review
- Takotsubo syndrome: left atrial and ventricular myocardial strain impairment in the subacute and convalescent phases assessed by CMR.European radiology experimental · 2024Article
- Left Atrial Strain Imaging by Speckle Tracking Echocardiography: The Supportive Diagnostic Value in Cardiac Amyloidosis and Hypertrophic Cardiomyopathy.Journal of cardiovascular development and disease · 2023Article
- Prognostic value of right ventricular global longitudinal strain in patients with immunoglobulin light-chain cardiac amyloidosis.European heart journal open · 2023Article
- Left Atrial Strain as a Predictor of Left Ventricular Diastolic Dysfunction in Patients with Arterial Hypertension.Medicina (Kaunas, Lithuania) · 2022Article
Corrections and comments
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Authors and funding
24 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThis study was performed to investigate whether left atrial (LA) strain by echocardiography provides prognostic information in patients with wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM). METHODS AND
resultsAmong 129 patients who were diagnosed with ATTRwt-CM at Kumamoto University Hospital from December 2002 to December 2019, 113 patients who had enough information for two-dimensional speckle tracking echocardiography were enrolled in this study. During a median follow-up of 668 days, 28 cardiovascular deaths occurred. Compared with patients in the non-event group, those in the cardiovascular death group were significantly older (81.5 ± 7.4 vs. 78.1 ± 6.1 years, P < 0.01), had a lower incidence of carpal tunnel syndrome (21% vs. 47%, P < 0.05), and had a higher high-sensitivity cardiac troponin T [0.085 (0.063-0.105) vs. 0.049 (0.036-0.079) ng/mL, P < 0.01] and B-type natriuretic peptide concentrations [419 (239-541) vs. 271 (155-462) pg/mL, P < 0.01] and lower estimated glomerular filtration rate (41.8 ± 15.4 vs. 53.4 ± 14.6 mL/min/1.73 m
conclusionsLeft atrial strain during the reservoir phase provides significant prognostic value in patients with ATTRwt-CM even after adjusting for conventional predictive factors.
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