ReviewClinical and translational allergy2021
Integration of in vitro allergy test results and ratio analysis for the diagnosis and treatment of allergic patients (INTEGRA).
Review in Clinical and translational allergy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Pathophysiological and molecular insights into allergic conjunctivitis: an expanding analysis of immunological endotypes.Frontiers in allergy · 2026Review
- The molecular landscape of peach allergy in Tunisia: new insights.Frontiers in immunology · 2026Article
- Identification of the primary sensitizing mite (dominant mite) in patients with allergic respiratory disease sensitized toThe World Allergy Organization journal · 2025Article
- Molecular Diagnosis in Hymenoptera Allergy: Comparison of Euroline DPA-Dx and ImmunoCAP.Toxins · 2025Article
- Allergen-specific IgE/total IgE ratio for food allergy diagnosis in children.Frontiers in pediatrics · 2025Article
- Allergen Testing: A Review of the Indications, Procedures, and Limitations in Ocular Allergy.Clinical reviews in allergy & immunology · 2024Review
- Article
- Back to basics: likelihood ratios for olive and grass pollen specific IgE in seasonal allergic rhinitis.Frontiers in allergy · 2023Article
- Low Levels Matter: Clinical Relevance of Low Pru p 3 sIgE in Patients With Peach Allergy.Frontiers in allergy · 2022Article
- Integration of in vitro allergy test results and ratio analysis for the diagnosis and treatment of allergic patients (INTEGRA).Clinical and translational allergy · 2021Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The introduction of molecular diagnosis into routine clinical practice has substantially improved the diagnosis and management of allergic patients by allowing clinicians to precisely identify the allergenic molecule responsible for immunoglobulin E (IgE)-mediated allergies. However, it can be challenging to accurately interpret the results of molecular assays, partly due to the limited evidence base. In this context, a panel of experts with extensive experience in interpreting in vitro measures of total and serum specific IgE reviewed the available scientific evidence. After this review, the panel selected a series of representative case studies to demonstrate how determination of specific and total IgE values and the relationship between them (ratio analysis) can add value to the diagnostic process by more precisely defining the patient's sensitization profile. Finally, the experts developed a series of recommendations on the clinical application of ratio analysis to optimize and complement the classical approach to allergy diagnosis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.