Evidence map›Paper›PMID 34582079›Full record

ArticlePlant biotechnology journal2022

Genome editing with type II-C CRISPR-Cas9 systems from Neisseria meningitidis in rice.

Rongfang Xu, Ruiying Qin, Hongjun Xie, Juan Li, Xiaoshuang Liu, Mingdong Zhu, Yang Sun, Yinghong Yu, Pingli Lu, Pengcheng Wei

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plant biotechnology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. CRISPR-Cas applications in agriculture and plant research.Nature reviews. Molecular cell biology · 2025
    Review
  6. BES-Designer: A Web Tool to Design Guide RNAs for Base Editing to Simplify Library.Interdisciplinary sciences, computational life sciences · 2025
    Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Adenine Base EditingGEN biotechnology · 2022
    Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Advances in CRISPR/Cas9.BioMed research international · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Rongfang XuCollege of Agronomy, Anhui Agricultural University, Hefei, China.
Ruiying QinKey Laboratory of Rice Genetic Breeding of Anhui Province, Rice Research Institute, Anhui Academy of Agricultural Sciences, Hefei, China.
Hongjun XieKey Laboratory of Indica Rice Genetics and Breeding in the middle and Lower Reaches of Yangtze River Valley, Ministry of Agriculture, Hunan Rice Research Institute, Changsha, China.
Juan LiKey Laboratory of Rice Genetic Breeding of Anhui Province, Rice Research Institute, Anhui Academy of Agricultural Sciences, Hefei, China.
Xiaoshuang LiuCollege of Agronomy, Anhui Agricultural University, Hefei, China.
Mingdong ZhuKey Laboratory of Indica Rice Genetics and Breeding in the middle and Lower Reaches of Yangtze River Valley, Ministry of Agriculture, Hunan Rice Research Institute, Changsha, China.
Yang SunState Key Laboratory of Crop Stress Adaptation and Improvement, Key Laboratory of Plant Stress Biology, School of Life Sciences, Henan University, Kaifeng, China.
Yinghong YuKey Laboratory of Indica Rice Genetics and Breeding in the middle and Lower Reaches of Yangtze River Valley, Ministry of Agriculture, Hunan Rice Research Institute, Changsha, China.
Pingli LuAnhui Provincial Key Laboratory of Molecular Enzymology and Mechanism of Major Diseases, College of Life Sciences, Anhui Normal University, Wuhu, China.
Pengcheng WeiCollege of Agronomy, Anhui Agricultural University, Hefei, China.ORCID 0000-0001-5403-9451
Anhui Agricultural University · CNHunan Rice Research Institute · CNRice Research Institute · CNAnhui Normal University · CNHenan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Two type II-C Cas9 orthologs (Nm1Cas9 and Nm2Cas9) were recently identified from Neisseria meningitidis and have been extensively used in mammalian cells, but whether these NmCas9 orthologs or other type II-C Cas9 proteins can mediate genome editing in plants remains unclear. In this study, we developed and optimized targeted mutagenesis systems from NmCas9s for plants. Efficient genome editing at the target with N

Indexed as

Neisseria meningitidisOryzaAdenineAnimalsAPOBEC-1 DeaminaseCRISPR-Cas SystemsCytidine DeaminaseGene EditingMammalsProteinsRatsAdenineAPOBEC-1 DeaminaseApobec1 protein, ratAPOBEC3A protein, humanCytidine DeaminaseProteinsCRISPRgenome editingNmCas9ricetype II-C

Identifiers

PMID34582079
PMCPMC8753361
OpenAlexW3202019887

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.