Evidence map›Paper›PMID 34581996›Full record

ReviewJournal of neurovirology2021

A comprehensive review of COVID-19 biology, diagnostics, therapeutics, and disease impacting the central nervous system.

Anastasia Williams, Heather Branscome, Pooja Khatkar, Gifty A Mensah, Sarah Al Sharif, Daniel O Pinto, Catherine DeMarino, Fatah Kashanchi

Abstract readReview
In one paragraph

Review in Journal of neurovirology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Neuro-Immune Interactions in Severe COVID-19 Infection.Pathogens (Basel, Switzerland) · 2022
    Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. COVID-19: The cynosure of rise of Parkinson's disease.International review of neurobiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anastasia WilliamsLaboratory of Molecular Virology, School of Systems Biology, George Mason University, Manassas, VA, USA.
Heather BranscomeLaboratory of Molecular Virology, School of Systems Biology, George Mason University, Manassas, VA, USA.
Pooja KhatkarLaboratory of Molecular Virology, School of Systems Biology, George Mason University, Manassas, VA, USA.
Gifty A MensahLaboratory of Molecular Virology, School of Systems Biology, George Mason University, Manassas, VA, USA.
Sarah Al SharifLaboratory of Molecular Virology, School of Systems Biology, George Mason University, Manassas, VA, USA.
Daniel O PintoLaboratory of Molecular Virology, School of Systems Biology, George Mason University, Manassas, VA, USA.
Catherine DeMarinoLaboratory of Molecular Virology, School of Systems Biology, George Mason University, Manassas, VA, USA.
Fatah KashanchiLaboratory of Molecular Virology, School of Systems Biology, George Mason University, Manassas, VA, USA. fkashanc@gmu.edu.ORCID 0000-0001-9681-2780

Funding

HIV1 INHIBITION USING TAT PEPTIDE DERIVATIVESR01AI043894 · NIAID · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI KASHANCHI, FATAH · 1999 to 2015
$4.4M
HIV neuropathogenesis related to exosomes containing HIV non-coding RNAsR01NS099029 · NINDS · GEORGE MASON UNIVERSITY · PI KASHANCHI, FATAH · 2016 to 2020
$1.9M
Effect of chromatin remodelers/modifiers on HIV-1 Tat activated transcriptionR21AI074410 · NIAID · GEORGE WASHINGTON UNIVERSITY · PI KASHANCHI, FATAH · 2009 to 2010
$432k
A radiation-induced cellular stress activates HIV and induces killing of infected cellsR21AI127351 · NIAID · GEORGE MASON UNIVERSITY · PI KASHANCHI, FATAH · 2016 to 2017
$418k
HIV-1 TAR derived miRNA: Implications for Latency and PathogenesisR21AI078859 · NIAID · GEORGE WASHINGTON UNIVERSITY · PI KASHANCHI, FATAH · 2009 to 2010
$400k
NIAID NIH HHS R01 AI043894NIAID NIH HHS R21 AI074410NIAID NIH HHS R21 AI078859NIAID NIH HHS R21 AI127351NIH HHS AI078859, AI074410, AI127351-01, AI043894, NS099029NINDS NIH HHS R01 NS099029
6 · The paper itself

Abstract

The ongoing COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a highly transmissible disease. SARS-CoV-2 is estimated to have infected over 153 million people and to have caused over 3.2 million global deaths since its emergence in December 2019. SARS-CoV-2 is the seventh coronavirus known to infect humans, and like other coronaviruses, SARS-CoV-2 infection is characterized by a variety of symptoms including general flu-like symptoms such as a fever, sore throat, fatigue, and shortness of breath. Severe cases often display signs of pneumonia, lymphopenia, acute kidney injury, cardiac injury, cytokine storms, lung damage, acute respiratory distress syndrome (ARDS), multiple organ failure, sepsis, and death. There is evidence that around 30% of COVID-19 cases have central nervous system (CNS) or peripheral nervous system (PNS) symptoms along with or in the absence of the previously mentioned symptoms. In cases of CNS/PNS impairments, patients display dizziness, ataxia, seizure, nerve pain, and loss of taste and/or smell. This review highlights the neurological implications of SARS-CoV-2 and provides a comprehensive summary of the research done on SARS-CoV-2 pathology, diagnosis, therapeutics, and vaccines up to May 5.

Indexed as

Central Nervous System DiseasesCOVID-19HumansSARS-CoV-2CNSCoronavirusCOVID-19SARS-CoV-2

Identifiers

PMID34581996
PMCPMC8477646

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.