Evidence map›Paper›PMID 34581906›Full record

ArticleBasic research in cardiology2021

The zinc transporter ZIP7 (Slc39a7) controls myocardial reperfusion injury by regulating mitophagy.

Hualu Zhang, Ningzhi Yang, Haiyan He, Junwu Chai, Xinxin Cheng, Huanhuan Zhao, Dongming Zhou, Tianming Teng, Xiangrong Kong, Qing Yang and 1 more

Abstract read
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In one paragraph

Article in Basic research in cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
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  5. Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Mitophagy in cardiovascular diseases: a literature review.Cardiovascular diagnosis and therapy · 2026
    Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Hualu Zhang *Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, 300070, China.
Ningzhi Yang *Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, 300070, China.
Haiyan He *Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, 300070, China.
Junwu Chai *Department of Cardiac Surgery, Tianjin First Central Hospital, Tianjin, 300192, China.
Xinxin ChengDepartment of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, 300070, China.
Huanhuan ZhaoDepartment of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, 300070, China.
Dongming ZhouDepartment of Pathogenic Biology, Tianjin Medical University, Tianjin, 300070, China.
Tianming TengDepartment of Cardiology, General Hospital, Tianjin Medical University, Tianjin, 300052, China.
Xiangrong KongDepartment of Cardiac Surgery, Tianjin First Central Hospital, Tianjin, 300192, China.
Qing YangDepartment of Cardiology, General Hospital, Tianjin Medical University, Tianjin, 300052, China.
Zhelong XuDepartment of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, 300070, China. zxu@tmu.edu.cn.
Tianjin Medical University · CNTianjin Medical University General Hospital · CNTianjin First Center Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Whereas elimination of damaged mitochondria by mitophagy is proposed to be cardioprotective, the regulation of mitophagy at reperfusion and the underlying mechanism remain elusive. Since mitochondrial Zn

Indexed as

Cation Transport ProteinsMyocardial Reperfusion InjuryReperfusion InjuryAnimalsCarrier ProteinsEndoplasmic ReticulumHumansMiceMitochondria, HeartMitophagyProtein KinasesZincCarrier ProteinsCation Transport ProteinsProtein KinasesSLC39A7 protein, humanSlc39a7 protein, mouseZinczinc-binding proteinMitochondrial Zn2+MitophagyReperfusion injuryROSZIP7

Identifiers

PMID34581906
OpenAlexW3204870335

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.