Evidence map›Paper›PMID 34581719›Full record

ArticleLab on a chip2021

Engineering of a functional pancreatic acinus with reprogrammed cancer cells by induced

Stephanie M Venis, Hye-Ran Moon, Yi Yang, Sagar M Utturkar, Stephen F Konieczny, Bumsoo Han

Open access · greenAbstract read
In one paragraph

Article in Lab on a chip, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Stephanie M VenisSchool of Mechanical Engineering, Purdue University, West Lafayette, IN 47907, USA. bumsoo@purdue.edu.
Hye-Ran MoonSchool of Mechanical Engineering, Purdue University, West Lafayette, IN 47907, USA. bumsoo@purdue.edu.
Yi YangDepartment of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA.
Sagar M UtturkarCenter for Cancer Research, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0002-3453-1948
Stephen F KoniecznyDepartment of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0002-3281-3714
Bumsoo HanSchool of Mechanical Engineering, Purdue University, West Lafayette, IN 47907, USA. bumsoo@purdue.edu.ORCID 0000-0001-9487-1090
Purdue University West Lafayette · US

Funding

Tumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Sara K Quinney · 1999 to 2026
$59.3M
Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI Andrea L Kasinski · 1985 to 2026
$43.4M
Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
Targeting the Plasminogen Activation System to Limit Pancreatic Cancer Progression and Associated ThrombosisU01HL143403 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FISHEL, MELISSA L., FLICK, MATTHEW J. · 2018 to 2022
$4.2M
Kras-Induced Cellular Plasticity in Pancreatic CancerR01CA124586 · NCI · PURDUE UNIVERSITY · PI KONIECZNY, STEPHEN F · 2008 to 2017
$3.1M
Thrombin-dependent mechanisms of pancreatic ductal adenocarcinoma diseaseR01CA211098 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FLICK, MATTHEW J. · 2017 to 2022
$2.2M
Investigation of novel signaling protein in 3D and in vivo PDAC models using second generation Ref-1 inhibitorsR01CA254110 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI FISHEL, MELISSA L., HAN, BUMSOO · 2021 to 2025
$2.1M
NCATS NIH HHS UL1 TR002529NCI NIH HHS P30 CA023168NCI NIH HHS P30 CA082709NCI NIH HHS R01 CA124586NCI NIH HHS R01 CA211098NCI NIH HHS R01 CA254110NHLBI NIH HHS U01 HL143403
6 · The paper itself

Abstract

A pancreatic acinus is a functional unit of the exocrine pancreas producing digest enzymes. Its pathobiology is crucial to pancreatic diseases including pancreatitis and pancreatic cancer, which can initiate from pancreatic acini. However, research on pancreatic acini has been significantly hampered due to the difficulty of culturing normal acinar cells

Indexed as

Pancreas, ExocrinePancreatic NeoplasmsAcinar CellsHumansPancreasTranscription FactorsTranscription Factors

Identifiers

PMID34581719
PMCPMC9175079
OpenAlexW3188192199

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.