ArticleJournal of dual diagnosis
Co-Occurring Opioid Use and Depressive Disorders: Patient Characteristics and Co-Occurring Health Conditions.
Article in Journal of dual diagnosis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Ketamine in treating opioid use disorder and opioid withdrawal: a scoping review.Frontiers in psychiatry · 2025Pooled it
- Clinical Characteristics of Patients With and Without Chronic Pain Seeking Behavioral Health Treatment for Co-Occurring Opioid Use and Mental Health Disorders.Substance use & addiction journal · 2026Trial
- Findings from an Organizational Context Survey to Inform the Implementation of a Collaborative Care Study for Co-occurring Disorders.The journal of behavioral health services & research · 2024Trial
- Genetic variation in BDNF is associated with opioid use disorder severity.Human genetics · 2026Article
- Integrating Clinical Priorities into the Technical Validation of Machine Learning Classifiers: A Generalizable Framework Demonstrated on Opioid Misuse Screening.Journal of clinical medicine · 2026Article
- Opioid Use Disorder and Treatment Uptake Among Patients With Rheumatic Conditions in the All of Us Research Program: A Descriptive Analysis.Arthritis care & research · 2026Article
- Higher suicidality among primary care patients who have opioid use disorder and co-occurring depression and/or PTSD.BMC primary care · 2026Article
- Antidepressants and the endogenous opioid system.Biochemical pharmacology · 2025Review
- The psychosocial pain management to improve opioid use disorder treatment outcomes study: Protocol for a randomized controlled trial.Contemporary clinical trials · 2025Article
- Retention Challenges in Opioid Use Disorder Treatment: The Role of Comorbid Psychological Conditions.The western journal of emergency medicine · 2025Article
- Healthcare utilization trends among patients with opioid use disorder in U.S. Hospitals: an analysis of length of stay, total charges, and costs, 2005-2020.BMC health services research · 2025Article
- The Association Between Internet Use and Co-occurring Health Care Needs: Cross-Sectional Study in China.Journal of medical Internet research · 2025Article
- Exploring social impairment in those with opioid use disorder: linking impulsivity, childhood trauma, and the prefrontal cortex.BMC psychiatry · 2025Article
- Psychosocial correlates of depression and anxiety among treatment-seeking individuals with opioid dependence: a cross-sectional study.Frontiers in psychiatry · 2025Article
- Exploring Social Impairment in Those with Opioid Use Disorder: Linking Impulsivity, Childhood Trauma, and the Prefrontal Cortex.Research square · 2024Article
- Understanding healthcare engagement for people who inject drugs.Research in nursing & health · 2024Article
- Developing a Framework to Infer Opioid Use Disorder Severity From Clinical Notes to Inform Natural Language Processing Methods: Characterization Study.JMIR mental health · 2024Article
- The impact of chronic pain and depression on medication for opioid use disorder treatment: A mixed-methods analysis.Heroin addiction and related clinical problems · 2024Article
- Patient Perspectives on Adapting Collaborative Care for Opioid Use Disorder With Depression and/or Post-traumatic Stress Disorder.Progress in community health partnerships : research, education, and action · 2024Article
- Psilocybin for Opioid Use Disorder in Two Adults Stabilized on Buprenorphine: A Technical Report on Study Modifications and Preliminary Findings.Psychedelic medicine (New Rochelle, N.Y.) · 2023Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectiveAmong persons with opioid use disorder (OUD), co-occurring depression is linked to a greater risk of opioid misuse, overdose and suicide. Less is known about characteristics and other comorbid health conditions of persons with co-occurring opioid use and depressive disorders.
methodsThis study used electronic health record (EHR) encounters from the Geisinger Health System prior to the fall of 2019. Adult patients were recruited from a medication-based treatment clinic and had an OUD diagnosis (
resultsForty-seven percent of patients with OUD had a lifetime depression diagnosis. Individuals with co-occurring depression were more likely to be female and have comorbid chronic pain or other medical conditions. Co-occurring depression was associated with an increased likelihood of other mental health and substance use disorders, as well as opioid overdose and/or suicide attempt or ideation.
conclusionsWhile it is established that co-occurring depression is associated with increased risk of overdose and suicide, this study adds that other health conditions, including chronic pain and common medical conditions, are more prevalent among persons with co-occurring depressive disorders. Results highlight the need to consider these complex health needs when developing treatment plans and services.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.