Evidence map›Paper›PMID 34581604›Full record

ArticleInfection and immunity2021

Transcriptional and Translational Responsiveness of the Neisseria gonorrhoeae Type IV Secretion System to Conditions of Host Infections.

Melanie M Callaghan, Amy K Klimowicz, Abigail C Shockey, John Kane, Caitlin S Pepperell, Joseph P Dillard

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Norepinephrine derepresses the Fur regulon ofJournal of bacteriology · 2026
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  6. Comparative Whole-Genome Analysis ofFrontiers in cellular and infection microbiology · 2022
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Melanie M CallaghanDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0002-3755-1979
Amy K KlimowiczDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Abigail C ShockeyDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
John KaneDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Caitlin S PepperellDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Joseph P DillardDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0003-1711-7670
University of Wisconsin–Madison · US

Funding

Type IV Secretion by Neisseria gonorrhoeaeR01AI047958 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI DILLARD, JOSEPH P · 2002 to 2019
$5.0M
NIAID NIH HHS R01 AI047958
6 · The paper itself

Abstract

The type IV secretion system of Neisseria gonorrhoeae translocates single-stranded DNA into the extracellular space, facilitating horizontal gene transfer and initiating biofilm formation. Expression of this system has been observed to be low under laboratory conditions, and multiple levels of regulation have been identified. We used a translational fusion of

Indexed as

Gene Expression Regulation, BacterialHost-Pathogen InteractionsType IV Secretion SystemsBacterial AdhesionBacterial ProteinsCopperGonorrheaHumansIronNeisseria gonorrhoeaeZincBacterial ProteinsCopperIronType IV Secretion SystemsZincbiofilmscopperiron regulationNeisseria gonorrhoeaephagosomestranscriptional regulationtranscriptometype IV secretionurethral infectionzinc

Identifiers

PMID34581604
PMCPMC8594608
OpenAlexW3130001760

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.