ArticleMolecular microbiology2021
Motility control through an anti-activation mechanism in Agrobacterium tumefaciens.
Article in Molecular microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- A clarifying perspective on bacterial pseudo-receiver domains.Journal of bacteriology · 2025Review
- Activation of the ChvG-ChvI pathway promotes survival during cell wall stress inMolecular biology of the cell · 2025Article
- Transcriptomic Analysis of the Negative Effect of Epigallocatechin-3-Gallate from Tea Plant (Current issues in molecular biology · 2025Article
- The motility and chemosensory systems of Rhizobium leguminosarum, their role in symbiosis, and link to PTSEnvironmental microbiology · 2024Article
- Metagenomic insights into the response of soil microbial communities to pathogenicFrontiers in plant science · 2024Article
- An Inducible T7 Polymerase System for High-Level Protein Expression in Diverse Gram-Negative Bacteria.Microbiology resource announcements · 2023Article
- A large-scale genetic screen identifies genes essential for motility in Agrobacterium fabrum.PloS one · 2023Article
- Activation of ChvG-ChvI regulon by cell wall stress confers resistance to β-lactam antibiotics and initiates surface spreading in Agrobacterium tumefaciens.PLoS genetics · 2022Article
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Authors and funding
5 authors.
Funding
Abstract
Many bacteria can migrate from a free-living, planktonic state to an attached, biofilm existence. One factor regulating this transition in the facultative plant pathogen Agrobacterium tumefaciens is the ExoR-ChvG-ChvI system. Periplasmic ExoR regulates the activity of the ChvG-ChvI two-component system in response to environmental stress, most notably low pH. ChvI impacts hundreds of genes, including those required for type VI secretion, virulence, biofilm formation, and flagellar motility. Previous studies revealed that activated ChvG-ChvI represses expression of most of class II and class III flagellar biogenesis genes, but not the master motility regulator genes visN, visR, and rem. In this study, we characterized the integration of the ExoR-ChvG-ChvI and VisNR-Rem pathways. We isolated motile suppressors of the non-motile ΔexoR mutant and thereby identified the previously unannotated mirA gene encoding a 76 amino acid protein. We report that the MirA protein interacts directly with the Rem DNA-binding domain, sequestering Rem and preventing motility gene activation. The ChvG-ChvI pathway activates mirA expression and elevated mirA is sufficient to block motility. This study reveals how the ExoR-ChvG-ChvI pathway prevents flagellar motility in A. tumefaciens. MirA is also conserved among other members of the Rhizobiales suggesting similar mechanisms of motility regulation.
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