ArticleCerebral cortex (New York, N.Y. : 1991)2022
Reduced Hippocampal-Striatal Interactions during Formation of Durable Episodic Memories in Aging.
Article in Cerebral cortex (New York, N.Y. : 1991), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Brain connectivity changes associated with episodic recollection decline in aging: A review of fMRI studies.Frontiers in aging neuroscience · 2022Pooled it
- Vulnerability to memory decline in aging revealed by a mega-analysis of structural brain change.Nature communications · 2025Article
- Absence of hippocampal pathology persists in the Q175DN mouse model of Huntington's disease despite elevated HTT aggregation.Journal of Huntington's disease · 2025Article
- Differential expression of spatiotemporal sleep spindle clusters in aging.Sleep advances : a journal of the Sleep Research Society · 2025Article
- Recalled through this day but forgotten next week?-retrieval activity predicts durability of partly consolidated memories.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Memory precision and age differentially predict the use of decision-making strategies across the lifespan.Scientific reports · 2023Article
- Sustained upregulation of widespread hippocampal-neocortical coupling following memory encoding.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
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9 authors.
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Abstract
Encoding of durable episodic memories requires cross-talk between the hippocampus and multiple brain regions. Changes in these hippocampal interactions could contribute to age-related declines in the ability to form memories that can be retrieved after extended time intervals. Here we tested whether hippocampal-neocortical- and subcortical functional connectivity (FC) observed during encoding of durable episodic memories differed between younger and older adults. About 48 younger (20-38 years; 25 females) and 43 older (60-80 years; 25 females) adults were scanned with fMRI while performing an associative memory encoding task. Source memory was tested ~20 min and ~6 days postencoding. Associations recalled after 20 min but later forgotten were classified as transient, whereas memories retained after long delays were classified as durable. Results demonstrated that older adults showed a reduced ability to form durable memories and reduced hippocampal-caudate FC during encoding of durable memories. There was also a positive relationship between hippocampal-caudate FC and higher memory performance among the older adults. No reliable age group differences in durable memory-encoding activity or hippocampal-neocortical connectivity were observed. These results support the classic theory of striatal alterations as one cause of cognitive decline in aging and highlight that age-related changes in episodic memory extend beyond hippocampal-neocortical connections.
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