ArticleeLife2021
Individual history of winning and hierarchy landscape influence stress susceptibility in mice.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Article
- Complex social dominance behavior using a novel platform test is associated with lateral habenula activation in male and female mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Article
- Social rank modulates empathic pain via Galntl6Molecular psychiatry · 2026Article
- Social hierarchy shapes behavioral and transcriptional responses to chronic stress and ketamine in male mice.iScience · 2026Article
- Region-specific neural activity changes and hierarchical instability following social isolation.iScience · 2026Article
- Social hierarchy and resilience affect stress-induced PTSD via Uba7 gene expression and subsequent inflammation in microglia of the mPFC.Molecular psychiatry · 2026Article
- Social rank and social environment combinedly affect REM sleep in mice.Scientific reports · 2026Article
- Adenosine A2A receptors in the nucleus accumbens regulate stress resilience and predict susceptibility to stress-induced affective disturbances.Purinergic signalling · 2026Article
- Cholinergic interneurons of the dorsomedial striatum mediate winner-loser effects on social hierarchy dynamics in male mice.iScience · 2025Article
- Article
- Article
- Social dominance in rats is a determinant of susceptibility to stress.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Heightened lateral habenula activity during stress produces brainwide and behavioral substrates of susceptibility.Neuron · 2024Article
- How can ethology inform the neuroscience of fear, aggression and dominance?Nature reviews. Neuroscience · 2024Review
- Analysis of behavioral flow resolves latent phenotypes.Nature methods · 2024Article
- A Multiparadigm Approach to Characterize Dominance Behaviors in CD1 and C57BL6 Male Mice.eNeuro · 2024Article
- Behavioral coping with chronic defeat stress in mice: A systematic review of current protocols.Neurobiology of stress · 2024Review
- Mesocorticolimbic circuit mechanisms of social dominance behavior.Experimental & molecular medicine · 2024Review
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Authors and funding
6 authors.
Funding
Abstract
Social hierarchy formation is strongly evolutionarily conserved. Across species, rank within social hierarchy has large effects on health and behavior. To investigate the relationship between social rank and stress susceptibility, we exposed ranked male and female mice to social and non-social stressors and manipulated social hierarchy position. We found that rank predicts same sex social stress outcomes: dominance in males and females confers resilience while subordination confers susceptibility. Pre-existing rank does not predict non-social stress outcomes in females and weakly does so in males, but rank emerging under stress conditions reveals social interaction deficits in male and female subordinates. Both history of winning and rank of cage mates affect stress susceptibility in males: rising to the top rank through high mobility confers resilience and mice that lose dominance lose stress resilience, although gaining dominance over a subordinate animal does not confer resilience. Overall, we have demonstrated a relationship between social status and stress susceptibility, particularly when taking into account individual history of winning and the overall hierarchy landscape in male and female mice.
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