Evidence map›Paper›PMID 34581186›Full record

ArticleThe British journal of radiology2021

The Wavelia Microwave Breast Imaging system-tumour discriminating features and their clinical usefulness.

Brian M Moloney, Peter F McAnena, Sami M Elwahab, Angie Fasoula, Luc Duchesne, Julio D Gil Cano, Catherine Glynn, AnnaMarie O'Connell, Rachel Ennis, Aoife J Lowery and 1 more

Abstract read
In one paragraph

Article in The British journal of radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Brian M MoloneyDiscipline of Surgery, Lambe Institute for Translational Research, School of Medicine, National University of Ireland Galway, Galway, Ireland.ORCID 0000-0003-3179-6657
Peter F McAnenaDiscipline of Surgery, Lambe Institute for Translational Research, School of Medicine, National University of Ireland Galway, Galway, Ireland.
Sami M ElwahabDepartment of Surgery, Galway University Hospital, Saolta University Healthcare Group, Galway, Ireland.
Angie FasoulaMVG Industries, Villejust, France.
Luc DuchesneMVG Industries, Villejust, France.
Julio D Gil CanoMVG Industries, Villejust, France.
Catherine GlynnDepartment of Radiology, Galway University Hospital, Saolta University Healthcare Group, Galway, Ireland.
AnnaMarie O'ConnellDepartment of Radiology, Galway University Hospital, Saolta University Healthcare Group, Galway, Ireland.
Rachel EnnisDepartment of Radiology, Galway University Hospital, Saolta University Healthcare Group, Galway, Ireland.
Aoife J LoweryDiscipline of Surgery, Lambe Institute for Translational Research, School of Medicine, National University of Ireland Galway, Galway, Ireland.
Michael J KerinDiscipline of Surgery, Lambe Institute for Translational Research, School of Medicine, National University of Ireland Galway, Galway, Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe Wavelia Microwave Breast Imaging (MBI) system, based on non-ionising imaging technology, has demonstrated exciting potential in the detection and localisation of breast pathology in symptomatic patients. In this study, the ability of the system to accurately estimate the size and likelihood of malignancy of breast lesions is detailed, and its clinical usefulness determined.

methodsInstitutional review board and Health Products Regulatory Authority (HPRA) approval were obtained. Patients were recruited from the symptomatic unit to three groups; breast cancer (Group-1), unaspirated cysts (Group-2) and biopsied benign lesions (Group-3). MBI, radiological and histopathological findings were reviewed. MBI size estimations were compared with the sizes determined by conventional imaging and histopathology. A Quadratic Discriminant Analysis (QDA) classifier was trained in a 3D feature space to discriminate malignant from benign lesions. An independent review was performed by two independent breast radiologists.

results24 patients (11 Group-1, 8 Group-2 and 5 Group-3) underwent MBI. The Wavelia system was more accurate than conventional imaging in size estimation of breast cancers. The QDA accurately separated benign from malignant breast lesions in 88.5% of cases. The addition of MBI and the Wavelia malignancy risk calculation was deemed useful by the two radiologists in 70.6% of cases.

conclusionThe results from this MBI investigation demonstrate the potential of this novel system in estimating size and malignancy risk of breast lesions. This system holds significant promise as a potential non-invasive, comfortable, and harmless adjunct for breast cancer diagnosis. Further larger studies are under preparation to validate the findings of this study. ADVANCES IN KNOWLEDGE: This study details the potential of the Wavelia MBI system in delineating size and malignancy risk of benign and malignant breast lesions in a symptomatic cohort. The usefulness of the Wavelia system is assessed in the clinical setting.

Indexed as

Microwave ImagingAdultAgedAged, 80 and overBreastBreast NeoplasmsDiagnosis, DifferentialFemaleHumansMiddle AgedReproducibility of Results

Identifiers

PMID34581186
PMCPMC8631021

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.