ArticleEMBO reports2021
Pseudomonas syringae senses polyphenols via phosphorelay crosstalk to inhibit virulence.
Article in EMBO reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- Hopeaphenol targets histidine kinase signaling across kingdoms to suppress bacterial virulence and potentiate plant immunity.bioRxiv : the preprint server for biology · 2026Article
- Plant-Derived Melatonin Inhibits Bacterial Virulence via CpxA/R Two-Component System.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A Dual-Receptor System MediatesJournal of agricultural and food chemistry · 2026Article
- Natural products for biocontrol ofFrontiers in plant science · 2026Review
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- Exploring the infection strategy ofFrontiers in plant science · 2025Article
- Metabolic profiling and antibacterial activity of tree wood extracts obtained under variable extraction conditions.Metabolomics : Official journal of the Metabolomic Society · 2024Article
- Plant secondary metabolite citral interferes with Phytophthora capsici virulence by manipulating the expression of effector genes.Molecular plant pathology · 2023Article
- Genome-Wide Analysis of Long Non-Coding RNAs Related to UV-B Radiation in the Antarctic MossInternational journal of molecular sciences · 2023Article
- Type III Secretion System Repressor RhpR Induces GrlP, a Glycine-Rich Outer Membrane Lipoprotein with Functions in Regulating the Periplasmic Space and Pleiotropic Responses.Applied and environmental microbiology · 2023Article
- Maintenance of tRNA and elongation factors supports T3SS proteins translational elongations in pathogenic bacteria during nutrient starvation.Cell & bioscience · 2022Article
- Virulence-related regulatory network ofComputational and structural biotechnology journal · 2022Review
- Pseudomonas syringae senses polyphenols via phosphorelay crosstalk to inhibit virulence.EMBO reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacteria use a variety of mechanisms, such as two-component regulatory systems (TCSs), to rapidly sense and respond to distinct conditions and signals in their host organisms. For example, a type III secretion system (T3SS) is a key determinant of the virulence of the model plant pathogen Pseudomonas syringae and contains the TCS RhpRS as a key regulator. However, the plant-derived compound targeting RhpRS remains unknown. Here, we report that RhpRS directly interacts with polyphenols and responds by switching off P. syringae T3SS via crosstalk with alternative histidine kinases. We identify three natural polyphenols that induce the expression of the rhpRS operon in an RhpS-dependent manner. The presence of these three specific polyphenols inhibits the phosphatase activity of RhpS, thus suppressing T3SS activation in T3SS-inducing conditions. The Pro40 residue of RhpS is essential to respond to these polyphenols. In addition, three non-cognate histidine kinases cooperatively phosphorylate RhpR and antagonize the rhpS mutant phenotype. This work illustrates that plant polyphenols can directly target P. syringae RhpRS, which results in bacterial virulence being switched off via a phosphorylation-related crosstalk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.