Evidence map›Paper›PMID 34580883›Full record

ArticleMedical physics2021

Experimental acoustic characterization of an endoskeletal antibubble contrast agent: First results.

Anastasiia Panfilova, Peiran Chen, Ruud J G van Sloun, Hessel Wijkstra, Michiel Postema, Albert T Poortinga, Massimo Mischi

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical physics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Anastasiia PanfilovaElectrical Engineering Department, Faculty of Electrical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
Peiran ChenElectrical Engineering Department, Faculty of Electrical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
Ruud J G van SlounElectrical Engineering Department, Faculty of Electrical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
Hessel WijkstraElectrical Engineering Department, Faculty of Electrical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
Michiel PostemaSchool of Electrical and Information Engineering, University of the Witwatersrand, Johannesburg, Braamfontein, South Africa.
Albert T PoortingaMechanical Engineering Department, Eindhoven University of Technology, Eindhoven, The Netherlands.
Massimo MischiElectrical Engineering Department, Faculty of Electrical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
Eindhoven University of Technology · NLAmsterdam University Medical Centers · NLTampere University · FI

Funding

eMTIC collaborationNational Research Foundation of South Africa 127102
6 · The paper itself

Abstract

purposeAn antibubble is an encapsulated gas bubble with an incompressible inclusion inside the gas phase. Current-generation ultrasound contrast agents are bubble-based: they contain encapsulated gas bubbles with no inclusions. The objective of this work is to determine the linear and nonlinear responses of an antibubble contrast agent in comparison to two bubble-based ultrasound contrast agents, that is, reference bubbles and SonoVue

methodsSide scatter and attenuation of the three contrast agents were measured, using single-element ultrasound transducers, operating at 1.0, 2.25, and 3.5 MHz. The scatter measurements were performed at acoustic pressures of 200 and 300 kPa for 1.0 MHz, 300 kPa, and 450 kPa for 2.25 MHz, and 370 and 560 kPa for 3.5 MHz. Attenuation measurements were conducted at pressures of 13, 55, and 50 kPa for 1.0, 2.25, and 3.5 MHz, respectively. In addition, a dynamic contrast-enhanced ultrasound measurement was performed, imaging the contrast agent flow through a vascular phantom with a commercial diagnostic linear array probe.

resultsAntibubbles generated equivalent or stronger harmonic signal, compared to bubble-based ultrasound contrast agents. The second harmonic side-scatter amplitude of the antibubble agent was up to 3 dB greater than that of reference bubble agent and up to 4 dB greater than that of SonoVue

conclusionEndoskeletal antibubbles generate comparable or greater higher harmonics than reference bubbles and SonoVue

Indexed as

AcousticsContrast MediaMicrobubblesPhantoms, ImagingPhysical PhenomenaUltrasonographyContrast Mediaharmonic imaginglinear attenuationnonlinear scatteringpickering-stabilised bubblesultrasound contrast agent

Identifiers

PMID34580883
PMCPMC9293338
OpenAlexW3201939934

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.