Evidence map›Paper›PMID 34580797›Full record

ArticleInfection2021

Screening paracoccidioidomycosis by double immunodiffusion test in a referred diagnostic center in Brazilian southeastern: an accessible tool.

Simone Bravim Maifrede, Wdson Luís Lima Kruschewsky, Suzana Alves Patrício, Aloísio Falqueto, Paulo Mendes Peçanha, Luiz Cosme Cotta Malaquias, Ana Paula Pôssa, Zoilo Pires de Camargo, Anderson Messias Rodrigues, Sarah Santos Gonçalves and 1 more

Abstract read
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In one paragraph

Article in Infection, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Simone Bravim MaifredeCenter for Research in Medical Mycology, Pathology Department, Federal University of Espírito Santo (UFES), Vitória, Brazil.
Wdson Luís Lima KruschewskyMedical Clinical Department, Federal University of Espírito Santo (UFES), Vitória, Brazil.
Suzana Alves PatrícioDentistry Department, Federal University of Espírito Santo (UFES), 1468, Marechal Campos Avenue, Vitória, ES, 29040-090, Brazil.
Aloísio FalquetoMedical Clinical Department, Federal University of Espírito Santo (UFES), Vitória, Brazil.
Paulo Mendes PeçanhaMedical Clinical Department, Federal University of Espírito Santo (UFES), Vitória, Brazil.
Luiz Cosme Cotta MalaquiasImmunology Department, Federal University of Alfenas (UNIFAL-MG), Alfenas, Brazil.
Ana Paula PôssaLaboratory of Emerging Fungal Pathogens, Department of Microbiology, Immunology, and Parasitology, Federal University of São Paulo (Unifesp), São Paulo, Brazil.
Zoilo Pires de CamargoLaboratory of Emerging Fungal Pathogens, Department of Microbiology, Immunology, and Parasitology, Federal University of São Paulo (Unifesp), São Paulo, Brazil.
Anderson Messias RodriguesLaboratory of Emerging Fungal Pathogens, Department of Microbiology, Immunology, and Parasitology, Federal University of São Paulo (Unifesp), São Paulo, Brazil.
Sarah Santos GonçalvesCenter for Research in Medical Mycology, Pathology Department, Federal University of Espírito Santo (UFES), Vitória, Brazil.ORCID http://orcid.org/0000-0003-4170-4445
Tânia Regina Grão-VellosoDentistry Department, Federal University of Espírito Santo (UFES), 1468, Marechal Campos Avenue, Vitória, ES, 29040-090, Brazil. taniag.velloso@gmail.com.ORCID http://orcid.org/0000-0001-6865-7955
Universidade Federal do Espírito Santo · BRUniversidade Federal de São Paulo · BRUniversidade Federal de Alfenas · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis article shows reports of the clinical-epidemiological characteristics and serological screening in patients assisted by a reference center for PCM care, University Hospital Cassiano Antonio Moraes, Federal University of Espirito Santo, Brazil.

methodsThe patient's sera with PCM were analyzed by DID test at the beginning and the end treatment. Clinical and demographic data were also collected to characterize the sample.

resultsOne hundred patients with a suspected diagnosis of PCM were evaluated. Serology by DID test was used as a screen in all patients. The test was positive for 79 patients (72 for Paracoccidioides brasiliensis and 7 for Paracoccidioides lutzii). Serology was negative in 21 sera, although all of them were diagnosed PCM by histopathologic or direct exam. Serological follow-up was performed during the treatment of all patients. After treatment, 58(58%) had negative serology and 33(33%) low levels of antibodies (≤ 1:16).

conclusionOur results indicate the importance of the DID test for the screening and monitoring of PCM and that the incidence of P. lutzii might be greater than expected in areas where it is not the predominant PCM species. Therefore, this article may contribute to improving the knowledge and clinical management about this disease.

Indexed as

ParacoccidioidomycosisAntigens, FungalBrazilHumansImmunodiffusionParacoccidioidesAntigens, FungalDiagnosisParacoccidioidomycosisSerologySystemic infection, mycosis, double immunodiffusion test

Identifiers

PMID34580797
OpenAlexW3203965262

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.