Observational studyAnnals of biomedical engineering2021
Changes in Tissue Composition and Load Response After Transtibial Amputation Indicate Biomechanical Adaptation.
Observational study in Annals of biomedical engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Bilateral Muscle Architecture Differences in a Rabbit Model of Unilateral Hindlimb Transtibial Amputation: A Pilot Study.Muscles (Basel, Switzerland) · 2026Article
- Comparisons of (cost-)effectiveness of manual, hybrid, and digital shape capture and shape design techniques for transtibial and transfemoral prosthetic sockets: A scoping review.Prosthetics and orthotics international · 2026Article
- The Effect of a Fully Immersive Virtual Reality Training Program on Walking Parameters in People With Unilateral Below-Knee Amputation: An Experimental and a Single-Subject Study.Health science reports · 2026Article
- [Hemodynamic study of muscle perfusion in amputees].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026Article
- Hyperspectral Imaging Reveals High Water and Hemoglobin Content at Rest and Decreased Oxygen Levels After Physical Activity at the Residual Limb of Non-Dysvascular Lower Limb Amputees.Microcirculation (New York, N.Y. : 1994) · 2026Article
- Skin adaptation in lower limb amputees assessed through Raman spectroscopy and mechanical characterization.Journal of the Royal Society, Interface · 2025Article
- Reconstruction of the Tibial Stump After Fibulectomy.Orthopedic research and reviews · 2025Article
- Application of ultrasound to monitor in vivo residual bone movement within transtibial prosthetic sockets.Scientific reports · 2024Article
- The Amputated Limb Gluteus Medius is Biomechanically Disadvantaged in Patients with Unilateral Transfemoral Amputation.Annals of biomedical engineering · 2024Article
- Modified motor unit properties in residual muscle following transtibial amputation.Journal of neural engineering · 2024Article
- Wound management, healing, and early prosthetic rehabilitation: Part 2 - A scoping review of physical biomarkers.Canadian prosthetics & orthotics journal · 2024Review
- Wound management, healing, and early prosthetic rehabilitation: Part 1 - A scoping review of healing and non-healing definitions.Canadian prosthetics & orthotics journal · 2024Review
- The impact of walking on the perception of multichannel electrotactile stimulation in individuals with lower-limb amputation and able-bodied participants.Journal of neuroengineering and rehabilitation · 2023Article
- Indications of musculoskeletal health in deceased male individuals with lower-limb amputations: comparison to non-amputee and diabetic controls.Scientific reports · 2023Article
- Ankle Torque Estimation With Motor Unit Discharges in Residual Muscles Following Lower-Limb Amputation.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2023Article
- A review of musculoskeletal adaptations in individuals following major lower-limb amputation.Journal of musculoskeletal & neuronal interactions · 2022Review
- Activity, socket fit, comfort and community participation in lower limb prosthesis users: a Cambodian cohort study.Journal of neuroengineering and rehabilitation · 2022Observational
- Editorial: Bionics limb prostheses: Advances in clinical and prosthetic care.Frontiers in rehabilitation sciences · 2022Article
- The Agonist-Antagonist Myoneural Interface in a Transtibial Amputation.JBJS essential surgical techniquesArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Despite the potential for biomechanical conditioning with prosthetic use, the soft tissues of residual limbs following lower-limb amputation are vulnerable to damage. Imaging studies revealing morphological changes in these soft tissues have not distinguished between superficial and intramuscular adipose distribution, despite the recognition that intramuscular fat levels indicate reduced tolerance to mechanical loading. Furthermore, it is unclear how these changes may alter tissue tone and stiffness, which are key features in prosthetic socket design. This study was designed to compare the morphology and biomechanical response of limb tissues to mechanical loading in individuals with and without transtibial amputation, using magnetic resonance imaging in combination with tissue structural stiffness. The results revealed higher adipose infiltrating muscle in residual limbs than in intact limbs (residual: median 2.5% (range 0.2-8.9%); contralateral: 1.7% (0.1-5.1%); control: 0.9% (0.4-1.3%)), indicating muscle atrophy and adaptation post-amputation. The intramuscular adipose content correlated negatively with daily socket use, although there was no association with time post-amputation. Residual limbs were significantly stiffer than intact limbs at the patellar tendon site, which plays a key role in load transfer across the limb-prosthesis interface. The tissue changes following amputation have relevance in the clinical understanding of prosthetic socket design variables and soft tissue damage risk in this vulnerable group.
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Registered trials
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